HOME >> BIOLOGY >> NEWS
Faulty cell membrane repair causes heart disease

During vigorous exercise, heart muscle cells take a beating. In fact, some of those cells rupture, and if not for a repair process capable of resealing cell membranes, those cells would die and cause heart damage (cardiomyopathy).

Researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine have discovered a specific repair mechanism in heart muscle and identified a protein called dysferlin that is critical for resealing heart muscle cell membranes.

The study, led by UI researcher and Howard Hughes Medical Institute investigator Kevin Campbell, Ph.D., also shows that loss of dysferlin causes cardiomyopathy in mice. Furthermore, heart damage in these mice is exaggerated by vigorous exercise or by inherent muscle weakness caused by a muscular dystrophy defect. The results are published in the July 1 issue of the Journal of Clinical Investigation.

Active tissues, like a beating heart or contracting muscle, need mechanisms to repair the inevitable cell membrane tears caused by physical stress and strain. In 2003, Campbell and his colleagues identified dysferlin as a key protein in this vital repair mechanism in skeletal muscle. In humans, dysferlin deficiency -- which leads to faulty muscle membrane repair -- causes three types of muscular dystrophy.

The new study expands knowledge of dysferlin function, showing that dysferlin-mediated membrane repair is also important in heart muscle cells and suggests that inadequate membrane repair can also lead to cardiomyopathy.

"If we could boost this repair mechanism, it might be possible to slow cardiac and skeletal muscle damage in muscular dystrophy patients," said Campbell who also holds the Roy J. Carver Biomedical Research Chair in Molecular Physiology and is head of the department and a UI professor of neurology.

The UI team initially found that young mice that lacked dysferlin showed no heart damage, which is consistent with what is
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
3-Jul-2007


Page: 1 2

Related biology news :

1. Faulty immune-priming cells start autoimmunity
2. Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
3. Faulty body clock leads to obesity and diabetes
4. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
5. University of Leeds strengthens China links in membrane and neurobiology
6. Semiconductor membrane mimics biological behavior of ion channels
7. Simulations unravel outer membrane transport mechanism
8. Elastic interactions of membrane proteins
9. Biologists prove critical step in membrane fusion
10. Penn scientists engineer small molecules to probe proteins deep inside cell membrane
11. One membrane, many frequencies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... , ... Lajollacooks4u has expanded its team as it gears up for a ... seen record growth in 2019, having hosted a multitude of team-building events and cooking ... visited the company’s La Jolla-based venue, and Lajollacooks4u has worked hard to accommodate the ...
(Date:8/27/2019)... Fla. (PRWEB) , ... August 27, 2019 , ... ... in life science and drug development. This episode is scheduled to broadcast 4Q/2019. ... explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show will ...
(Date:8/21/2019)... ... August 20, 2019 , ... Cutting Edge ... for the spine, today announced the 510(K) clearance of its novel SI joint ... is proven to improve osseointegration through superior hydrophilicity and optimized surface chemistry, as ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... sales and service organizations, today announced that the company’s Studio Intelligent Virtual Agent ... IVA market . Inference will officially accept the award at Frost & Sullivan’s ...
(Date:8/6/2019)... Ill. (PRWEB) , ... August 05, 2019 , ... ... that Jason Casarella has been recognized as a distinguished leader by PharmaVOICE magazine, ... featured in an article in the magazine’s July/August special issue. , As the ...
(Date:7/26/2019)... ... July 25, 2019 , ... ... through off-the-record collaboration and dialogue, today announces its Boston BD conference ... As part of Biotech Week Boston , the event provides an opportunity ...
Breaking Biology Technology:
Cached News: