HOME >> BIOLOGY >> NEWS
Faulty immune-priming cells start autoimmunity

HOUSTON -- (Feb. 24, 2006) The failure of programming that sparks the death of dendritic cells those that activate the immune system can initiate autoimmune disease, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Science.

The problem begins with a process called programmed cell death or apoptosis, said Dr. Jin Wang, assistant professor of immunology at Baylor College of Medicine. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease, he said.

"This suggests that defective apoptosis of dendritic cells can be a critical component of autoimmune diseases," said Wang.

Autoimmune diseases, such as juvenile diabetes and lupus, result when the immune system begins attacking the body's own tissues rather than foreign bodies.

"We knew that autoimmunity in general can be caused when dendritic cells are unchecked, either by programmed cell death or overactivation," said Wang.

"Dendritic cells are the initiators of immunity," said Wang.

They do this by showing or presenting foreign antigens from invading bacteria or viruses to the immune system, which then activates lymphocytes to attack.

Previously, many people thought autoimmunity occurred through apoptosis because of accumulating lymphocytes or white blood cells key elements of the immune system.

"If they didn't die, we thought they would start to accumulate and do damage to the body's own tissues," he said. However, at least eight studies that suppressed programmed cell death in lymphocytes did not induce autoimmune disease in animals.

In the future, Wang said, he and his colleagues plan to fill in the gaps between what happens when apoptosis is hindered in the dendritic cells and the occurrence of autoimmune disease.


'"/>

Contact: Ross Tomlin
htomlin@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
27-Feb-2006


Page: 1

Related biology news :

1. Faulty cell membrane repair causes heart disease
2. Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
3. Faulty body clock leads to obesity and diabetes
4. Newly created cancer stem cells could aid breast cancer research
5. ESF EURYI award winner aims to stop cancer cells reading their own DNA
6. OHSU turns mouse into factory for human liver cells
7. UCLA scientists produce functioning neurons from human embryonic stem cells
8. UCF research links proteins, stem cells and potential Alzheimers treatment
9. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
10. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
11. How cells change the pace of their steps

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
(Date:8/7/2020)... ... 06, 2020 , ... Nine middle school teachers from eight ... a unique professional development program that provides advanced STEM (science, technology, engineering and ... nationwide. , Created in partnership between the National Stem Cell Foundation and The ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont Nutrition ... in Wuxi, China. The new plant operation will provide the local animal production ... , “This facility will improve the flexibility of our offerings to the ...
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/7/2020)... THE WOODLANDS, Texas (PRWEB) , ... August 06, ... ... gene therapy and DNA vaccine industries, announces it has closed on the purchase ... Deison Technology Park in Conroe, TX and includes over 21 acres in the ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
Breaking Biology Technology:
Cached News: