HOME >> BIOLOGY >> NEWS
Faulty immune-priming cells start autoimmunity

HOUSTON -- (Feb. 24, 2006) The failure of programming that sparks the death of dendritic cells those that activate the immune system can initiate autoimmune disease, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Science.

The problem begins with a process called programmed cell death or apoptosis, said Dr. Jin Wang, assistant professor of immunology at Baylor College of Medicine. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease, he said.

"This suggests that defective apoptosis of dendritic cells can be a critical component of autoimmune diseases," said Wang.

Autoimmune diseases, such as juvenile diabetes and lupus, result when the immune system begins attacking the body's own tissues rather than foreign bodies.

"We knew that autoimmunity in general can be caused when dendritic cells are unchecked, either by programmed cell death or overactivation," said Wang.

"Dendritic cells are the initiators of immunity," said Wang.

They do this by showing or presenting foreign antigens from invading bacteria or viruses to the immune system, which then activates lymphocytes to attack.

Previously, many people thought autoimmunity occurred through apoptosis because of accumulating lymphocytes or white blood cells key elements of the immune system.

"If they didn't die, we thought they would start to accumulate and do damage to the body's own tissues," he said. However, at least eight studies that suppressed programmed cell death in lymphocytes did not induce autoimmune disease in animals.

In the future, Wang said, he and his colleagues plan to fill in the gaps between what happens when apoptosis is hindered in the dendritic cells and the occurrence of autoimmune disease.


'"/>

Contact: Ross Tomlin
htomlin@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
27-Feb-2006


Page: 1

Related biology news :

1. Faulty cell membrane repair causes heart disease
2. Faulty cell cycle checkpoints linked to lung cancer risk in African-Americans
3. Faulty body clock leads to obesity and diabetes
4. Newly created cancer stem cells could aid breast cancer research
5. ESF EURYI award winner aims to stop cancer cells reading their own DNA
6. OHSU turns mouse into factory for human liver cells
7. UCLA scientists produce functioning neurons from human embryonic stem cells
8. UCF research links proteins, stem cells and potential Alzheimers treatment
9. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
10. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
11. How cells change the pace of their steps

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use fingerprints instead ... National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in ... the boarding process to allow eligible Delta SkyMiles Members who are enrolled ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
Breaking Biology Technology:
Cached News: