HOME >> BIOLOGY >> NEWS
Feedback loop found that could forestall liver disease

DALLAS Oct. 11, 2005 Researchers at UT Southwestern Medical Center have discovered that the small intestine communicates with the liver to control the production of bile acids a finding that has great medical implications in treating people at risk for certain types of liver disease.

"We've discovered a new hormone, and new hormones are always exciting," said Dr. Steven Kliewer, professor of molecular biology and pharmacology and senior author of a study available online and appearing in the October issue of Cell Metabolism.

The findings may eventually play a role in understanding and preventing liver damage that can occur in biliary cirrhosis, viral hepatitis, alcoholic liver disease and pregnancy.

The central elements in the research are the body's bile acids powerful and essential detergents that help digest fatty foods and fat-soluble vitamins in the small intestine.

The liver makes bile acids out of cholesterol and sends them to the gall bladder, where they're stored until food is digested. The presence of food stimulates the gall bladder into releasing the bile acids to the small intestine, where they do their work. Finally, they're absorbed into the bloodstream and returned to the liver.

Because they're so powerful, bile acids can damage the body if not controlled properly.

"These bile acids are really nasty in terms of being strong detergents," said Dr. Kliewer, holder of the Nancy B. and Jake L. Hamon Distinguished Chair in Basic Cancer Research.

Scientists have previously known about a mechanism within the liver that prevents too much bile acid from being produced. Normally, a protein called CYP7A1 stimulates production of the acids. When enough bile acids are made, they trigger a series of reactions that blocks the gene for CYP7A1, and production stops.

For this study, UT Southwestern researchers looked at a protein in mice called fibroblast growth factor 15 (FGF15), which is part of a cascade of chemical
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
11-Oct-2005


Page: 1 2 3

Related biology news :

1. Waters off Washington state only second place in world where glass sponge reefs found
2. First new multiple sclerosis gene found in 30 years
3. Obesity found to be a risk factor for multiple myeloma
4. Antibody-altering protein found in developing B cells
5. New use for a cell toxin found to inhibit survival proteins in cancer cells
6. New way to target and kill antibiotic-resistant bacteria found
7. Soil particles found to boost prions capacity to infect
8. Support for chromosomal theory of cancer found in cancers development of drug resistance
9. Massive herds of animals found to still exist in Southern Sudan
10. Origins of nervous system found in genes of sea sponge, report scientists at UC Santa Barbara
11. Origins of nervous system found in genes of sea sponge

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... WEST LAFAYETTE, Ind. (PRWEB) , ... June 10, 2019 , ... ... Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published ... A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Purdue University. ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% from Q1-18. ... successful roll-out of strategic investments & operational excellence initiatives worldwide. , Laurent ...
(Date:6/4/2019)... ... 2019 , ... Lajollacooks4u is delighted to announce it has been named as ... is given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, ... , To qualify for the Certificate of Excellence –- an award that only 10 ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... (PRWEB) , ... June 11, 2019 , ... ... of Personalized Stem Cells Inc. (PSC) , has announced that their GMP ... Health, Food and Drug Branch for manufacturing. This is an important milestone ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ., a full-service ... today that they will be receiving 3 awards at the 2019 CRO Leadership Awards, ... awards in the categories of overall Quality and Compatibility (Access to desired markets, cultural ...
(Date:5/31/2019)... Redwood City, California (PRWEB) , ... ... ... received allowance of our patent applications from the USPTO providing proprietary interest ... SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP ...
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
Breaking Biology Technology:
Cached News: