HOME >> BIOLOGY >> NEWS
Females more prone to brain damage from alcohol abuse

PORTLAND, Ore. - Alcoholism has traditionally been considered a male disease because there are many more alcoholic males than females.

But a new study by researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center suggests that women are more prone to brain damage from alcohol abuse than men.

The study led by Kristine Wiren, Ph.D., associate professor of behavioral neuroscience and medicine, OHSU School of Medicine, and research biologist, PVAMC Research Service, found that female mice are more susceptible to neurotoxic effects of alcohol withdrawal, including significantly increased brain cell death, than male mice. It also found the gender difference exists whether the animals are prone to severe withdrawal due to a genetic predisposition, or resistant to it.

Wiren said she was surprised by the results.

"We designed the experiment to be able to identify gene expression differences between lines of mice that are genetically selected for severe alcohol withdrawal compared with mice that are resistant to alcohol withdrawal," Wiren said. "I thought there would be a difference between the genders, but I didn't think it would be the most important thing."

She added, "The withdrawal severity phenotypes do show some differences, but they're subtle."

The study appears in the online edition of the journal Neuropsychopharmacology.

Wiren and Joel Hashimoto, research associate of behavioral neuroscience at OHSU and the PVAMC Research Service, examined four groups of selectively bred mice: two female groups, including one prone to severe withdrawal and one resistant to severe withdrawal, and two similar male groups. Four control groups also were used.

Using DNA microarray or "gene chip" analysis, a laboratory process involving advanced robotics that allows large numbers of genes and their complex interactions to be observed, Wiren and Hashimoto examined 5,00
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
25-Jul-2007


Page: 1 2 3

Related biology news :

1. Females do best if they wait a while
2. Females, alcohol and hormones
3. Accident-prone? Scientists link brain function to knee injuries
4. Bernese Mountain Dogs prone to Borrelia burgdorferi infection
5. Children of allergy sufferers prone to same problem
6. Man, chimp difference may have made us prone to cancer
7. By age 6, children of overweight mothers are also prone to obesity
8. Invasion of the brain tumors
9. Preclinical study links gene to brain aneurysm formation
10. Gene variant is associated with brain anatomy, clinical course of ADHD
11. Human knowledge is based upon directed connectivity between brain areas

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2019)... , ... April 04, 2019 , ... ... with integrated linear encoders providing 0.05 microns and 0.005 microns resolution, respectively. The ... and drive variations are available, from fast DC-servo motors with linear encoders and ...
(Date:4/4/2019)... ... April 02, 2019 , ... The live session ... into the connectivity between product risk management (ISO 14971) and the clinical risk ... process. , With increasing global regulation and reimbursement challenges faced by medical device ...
(Date:4/1/2019)... (PRWEB) , ... April 01, 2019 , ... ... and System for Characterizing Skin Related Conditions” by the US Patent and Trademark ... The patent is an invention by uBiome collaborators Dr. Zachary Apte, Dr. ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny ... for approximately two months. After a series of diagnostics, an MRI was performed ... owner, Alison, researched the injury and found that VetStem Regenerative Cell Therapy ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
(Date:4/4/2019)... (PRWEB) , ... April 03, 2019 , ... ... together through intimate off-the-record collaboration and dialogue, today announces its Boston CEO conference ... offers insights into the industry’s challenges and opportunities with high-level panels and discussions ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, ... importance of healthy meals and good nutrition. This month, Chef Jodi Abel appeared ... chef. , The first segment addressed the nutritional value of USDA’s MyPlate, ...
Breaking Biology Technology:
Cached News: