HOME >> BIOLOGY >> NEWS
Fetal heart-cell enzyme important in onset of heart failure

trols the growth and multiplication of cells. Inpp5f is also related to tumor-suppressor genes involved in cancer.

"HDAC and Inpp5f give us new targets for regulating cardiac hypertrophy," says Epstein. "Inhibitors of HDAC may warrant testing for cardiac disease to stop the hypertrophy that accompanies the re-expression of the fetal-gene program."

HDAC inhibitors are already in trials for cancer and one, valproic acid, has been used for years to treat seizures. Most CHF medications are aimed at regulating blood pressure, but very few are targeted at the heart-muscle cells themselves. About 5 million Americans are living with CHF today, according to the American Heart Association.

"To understand how to better treat heart disease at the cellular level is an important next step," says Epstein.


'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
18-Feb-2007


Page: 1 2

Related biology news :

1. Fetal exposure to toxins could be behind rise in asthma
2. Choline during pregnancy may avoid, reverse some Fetal Alcohol Syndrome nervous disorders
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
5. NIEHS researchers identify enzyme critical in DNA replication
6. Scientists discover role of enzyme in DNA repair
7. Researchers create model of cancer-preventing enzyme, study how it works
8. Viral enzyme recruited in fight against ear infection
9. RNA enzyme structure offers a glimpse into the origins of life
10. Researchers create artificial enzyme that mimics the bodys internal engine
11. Scientists identify specific enzymes that make meningitis hard to fight

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/21/2016)... 2016 Unique technology combines ... superior security   Xura, Inc. ... secure digital communications services, today announced it is working ... enterprise customers, particularly those in the Financial Services Sector, ... authentication within a mobile app, alongside, and in combination ...
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
(Date:3/10/2016)...   Unisys Corporation (NYSE: UIS ) today ... is testing its biometric identity solution at the Otay Mesa ... help identify certain non-U.S. citizens leaving the country. ... help determine the efficiency and accuracy of using biometric technologies ... run until May 2016. --> the United ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven Pharmaceutical Holding ... has granted the company’s orphan drug designation request covering BHV-4157 for the treatment ... by the FDA. , Spinocerebellar ataxia is a rare, debilitating neurodegenerative disorder ...
(Date:5/23/2016)... , ... May 23, 2016 , ... The need for blood donations in South Texas ... by the South Texas Blood & Tissue Center, blood donations are on the decline. In ... and they are down 21 percent in South Texas in the last four years alone. ...
(Date:5/23/2016)... , ... May 23, 2016 , ... ... management solutions and services based in Aurora, Ohio, has broken ground on a ... in the Research Triangle Park area, this new location solidifies a commitment to ...
(Date:5/20/2016)... ... , ... Korean researchers say Manumycin A triggers apoptosis, or natural cell death, ... the disease. Surviving Mesothelioma has just posted an article on the new study. ... their mesothelioma study on the fact the Manumycin A, a derivative of Streptomyces parvulus, ...
Breaking Biology Technology:
Cached News: