HOME >> BIOLOGY >> NEWS
Fetal heart-cell enzyme important in onset of heart failure

trols the growth and multiplication of cells. Inpp5f is also related to tumor-suppressor genes involved in cancer.

"HDAC and Inpp5f give us new targets for regulating cardiac hypertrophy," says Epstein. "Inhibitors of HDAC may warrant testing for cardiac disease to stop the hypertrophy that accompanies the re-expression of the fetal-gene program."

HDAC inhibitors are already in trials for cancer and one, valproic acid, has been used for years to treat seizures. Most CHF medications are aimed at regulating blood pressure, but very few are targeted at the heart-muscle cells themselves. About 5 million Americans are living with CHF today, according to the American Heart Association.

"To understand how to better treat heart disease at the cellular level is an important next step," says Epstein.


'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
18-Feb-2007


Page: 1 2

Related biology news :

1. Fetal exposure to toxins could be behind rise in asthma
2. Choline during pregnancy may avoid, reverse some Fetal Alcohol Syndrome nervous disorders
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
5. NIEHS researchers identify enzyme critical in DNA replication
6. Scientists discover role of enzyme in DNA repair
7. Researchers create model of cancer-preventing enzyme, study how it works
8. Viral enzyme recruited in fight against ear infection
9. RNA enzyme structure offers a glimpse into the origins of life
10. Researchers create artificial enzyme that mimics the bodys internal engine
11. Scientists identify specific enzymes that make meningitis hard to fight

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... , June 23, 2016 On ... session at 4,833.32, down 0.22%; the Dow Jones Industrial Average ... 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez ... Inc. (NASDAQ: BIND ). Learn more about these ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... new line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC ... in Chicago. The result of a collaboration among several companies with expertise in ...
Breaking Biology Technology:
Cached News: