Fetal heart-cell enzyme important in onset of heart failure

trols the growth and multiplication of cells. Inpp5f is also related to tumor-suppressor genes involved in cancer.

"HDAC and Inpp5f give us new targets for regulating cardiac hypertrophy," says Epstein. "Inhibitors of HDAC may warrant testing for cardiac disease to stop the hypertrophy that accompanies the re-expression of the fetal-gene program."

HDAC inhibitors are already in trials for cancer and one, valproic acid, has been used for years to treat seizures. Most CHF medications are aimed at regulating blood pressure, but very few are targeted at the heart-muscle cells themselves. About 5 million Americans are living with CHF today, according to the American Heart Association.

"To understand how to better treat heart disease at the cellular level is an important next step," says Epstein.


Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Page: 1 2

Related biology news :

1. Fetal exposure to toxins could be behind rise in asthma
2. Choline during pregnancy may avoid, reverse some Fetal Alcohol Syndrome nervous disorders
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
5. NIEHS researchers identify enzyme critical in DNA replication
6. Scientists discover role of enzyme in DNA repair
7. Researchers create model of cancer-preventing enzyme, study how it works
8. Viral enzyme recruited in fight against ear infection
9. RNA enzyme structure offers a glimpse into the origins of life
10. Researchers create artificial enzyme that mimics the bodys internal engine
11. Scientists identify specific enzymes that make meningitis hard to fight

Post Your Comments:

(Date:9/26/2015)... 26th, 2015  Results of a TactioRPM pilot ... today at the Stanford Medicine X Conference. In ... Dashboards, Connected Health Devices and Pharmacogenomics", Roger ... will explain how senior patients equipped with connected ... pharmacist via the TactioRPM remote patient monitoring platform ...
(Date:9/24/2015)... September 24, 2015 ... 2015 Kerv ( http://kerv.com ... lanserar idag världens första kontaktlösa betalningsring på ... 77 000 GBP för massproduktion via crowdfunding.  ... ) , Kerv-bärare kan göra ...
(Date:9/10/2015)... -- Report Details Emerging Biological Drugs ... Revenue Prospects to Help You Stay Ahead ... drug classes? Get the latest technological and commercial ... data and industry knowledge, benefitting your influence. And ... sales predictions. Visiongain,s new study reveals what,s ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... , Oct. 12, 2015 /PRNewswire/ - Aeterna Zentaris ... biopharmaceutical company engaged in developing and commercializing novel treatments ... departure of Dennis Turpin , the Company,s former ... to close its Quebec City ... President and Chief Executive Officer of the Company commented, ...
(Date:10/12/2015)... LabStyle Innovations Corp. (OTCQB: ... announced its Medical Director, Dr. Moshe Kamar , ... 5th EAI International Conference on Wireless Mobile Communication and ... mobile and wireless technologies," the conference will take place ... 14 - 16, 2015. The conference is endorsed and ...
(Date:10/12/2015)... , Oct. 12, 2015 VolitionRx Limited ... completed clinical study of its NuQ ® blood-based test ... online issue of Clinical Epigenetics , the official journal ... in collaboration with Lund University, ... , MD, PhD, Professor of Surgery and Vice-Dean, Faculty of ...
(Date:10/12/2015)... ... October 12, 2015 , ... NeuMedics Inc., is a specialty biopharmaceutical ... that can safely and chronically be administered as an eye drop, announced today it ... The Cleveland Clinic and taking place October 25th to October 28th at The Cleveland ...
Breaking Biology Technology:
Cached News: