Fighting breast cancer

Toronto (August 16, 2005) - A senior scientist at Sunnybrook & Women's is one of four principal investigators in a multidisciplinary program that has received $3.36 million to study the metastasis of breast cancer. Dr. Arun Seth, a leader in genomics research, is the sole Toronto recipient of an award funded by a special competition of the Canadian Breast Cancer Research Alliance (CBCRA).

Seth's project, one of four in the program that aims to speed the development of metastasis-specific diagnostics and therapeutics, will receive $860,000 over five years to study how to predict which tumours in the breast will spread to bone.

"There is no model so far that allows you to predict that this tumour will go to bone, that this one will go somewhere else," says Seth. That's why he and bone biologist Jane Aubin, a co-investigator who is at the University of Toronto, created a unique mouse model that allows them to put human bone into it and then inject tumour cells into the bone to see if the cells grow. The model is the first that will enable scientists to use the same microenvironment - human cells and human bone - to study how breast cancer spreads. Typically, scientists inject human cells into a mouse-only microenvironment, which doesn't allow for confidence in interpreting results.

"My idea is to predict early on whether a tumour will metastasize, first of all, and second if it will go to bone or the liver or the lungs," says Seth. He and his colleagues will do this by dividing a tumour sample into at least two parts and injecting one part into the bone in the mouse. If it spreads, they will remove it and compare its molecular make-up to that of the sample that remained outside the mouse.

"What we hope to find is that the genetic makeup is already altered. That way we'll know if there are common changes. Then we can tell what will happen without waiting for metastases to occur, and those women can be treated aggressively."

Contact: Jennifer White
University of Toronto

Page: 1 2

Related biology news :

1. Fighting for their attention
2. Fighting to keep Darwin in the classroom
3. Fighting influenza and co. with 40,000 blood samples
4. Fighting like a girl or boy determined by gene in fruit flies
5. Fighting cancer with aspirin?
6. Fighting nutrition misinformation:
7. National Academies advisory: Fighting infectious disease
8. Fighting malaria by manipulating mosquitoes sense of smell
9. Newly created cancer stem cells could aid breast cancer research
10. New study suggests Concord grape juice may provide protection against breast cancer
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:

(Date:11/13/2018)... ... , ... Kenall has enhanced the popular MedMaster MAEC Series LED luminaires with ... luminaires are equipped with symmetric ambient and asymmetric exam modes, and an IP65 rating ... be specified in pairs, the MAEC is 8” x 48” and has a delivered ...
(Date:11/7/2018)... ... November 07, 2018 , ... Features such ... adjust to last-minute changes all contribute to client retention and referral business in ... travel and expense services provider says 80 percent of its new business is ...
(Date:11/6/2018)... SAN FRANCISCO (PRWEB) , ... November 06, 2018 , ... ... Professor of Biochemistry and Biophysics at the University of California, San Francisco (UCSF) and ... served as a scientific adviser to uBiome since 2013, and we are honored that ...
Breaking Biology News(10 mins):
(Date:10/24/2018)... ... October 23, 2018 , ... ... announced a new, exciting brand for its recently created biologics solutions business unit. ... Biologics Biotherapeutics portfolio of products, and henceforth will be known as ForteBio. It ...
(Date:10/18/2018)... ... October 18, 2018 , ... ... laboratory in the San Francisco Bay Area has received accreditation from the College ... patient safety. , Predicine received CAP accreditation for its Shanghai facility last month. ...
(Date:10/17/2018)... ... October 17, 2018 , ... Dr. Richard Amato, founder ... Michael Kang, are offering current and new patients the opportunity to enjoy improved ... emerging, proven treatment technology known as Piezosurgery® . As long-time believers in ...
(Date:10/17/2018)... ... 2018 , ... PathSensors’ cutting-edge CANARY based assays for the ... and Plant Health Inspection Service for use in regulatory diagnostics. By going through ... they will be able to rapidly and accurately test and identify these damaging ...
Breaking Biology Technology:
Cached News: