HOME >> BIOLOGY >> NEWS
Finding a cellular Neverland: How stem cells stay childlike

La Jolla, CA - Despite their celebrated "immortality," the capacity of embryonic stem (ES) cells for endless division has its limits. After a very extended childhood spent dividing in a culture dish, even stem cells tend to grow up and assume adult roles as workaday nerve, muscle, or blood cells, never to return to their youthful state.

How some ES cells succeed in recapturing lost cellular innocence and start anew once they begin maturing is described in a forthcoming study in Proceedings of the National Academy of Sciences, authored by a team of scientists from the Salk Institute for Biological Studies.

The team, headed by professor Juan Carlos Ispiza Belmonte, Ph.D., of the Gene Expression Laboratory and including professor Fred Gage, Ph.D., of the Laboratory of Genetics, demonstrates how a DNA-binding protein called Nanog coaxes mouse ES cells trying to differentiate into muscle cells back into an immature state. Nanog is named for the legendary Celtic land Tir nan Og where people remained forever young

"Embryonic stem cells represent enormous hope for treating otherwise incurable diseases," says Belmonte. "But before we can design therapeutic strategies or introduce these cells into patients, we must learn how to differentiate them into specific cell types and how to tame their formidable proliferating ability," he explains.

Nanog is a critical factor required for what cell biologists call "stemness," which is defined by two qualities: the ability of ES cells to divide or "self-renew" and their plasticity in assuming the identity of almost any cell type, which is also known as "pluripotency."

In a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few ES cells in a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMP. But when those maturing cells were forced to produce Nanog, they re
'"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
26-Jun-2006


Page: 1 2 3

Related biology news :

1. Finding protection from tumor growth in unexpected places
2. Finding the white wine difference
3. Finding an answer to Darwins Dilemma
4. Finding a cure for cancer: The holy grail of science
5. Finding the right mix: A biomaterial blend library
6. Finding paves way for better treatment of autoimmune disease
7. Finding about cellular microtubule rigidity could lead to development of new nano-materials
8. Findings by Einstein scientists reveal possible strategy against obesity, diabetes and infertility
9. Finding of a new molecular marker of resistance to chemotherapy in breast cancer
10. Finding a virus is not all bad news
11. Finding life on Mars and outer space begins by examining Earths inner space

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: