"We've long suspected acetaldehyde's role in the carcinogenicity of alcohol beverage consumption, but this study gives us important new clues about its involvement," says Ting-Kai Li, M.D., director of the NIAAA, part of the National Institutes of Health. "This work provides an important framework for understanding the underlying chemical pathway that could explain the association between drinking and certain types of cancer."
The research team, led by P.J. Brooks, Ph.D., of NIAAA and Miral Dizdaroglu, Ph.D., of NIST, examined acetaldehyde's reaction with polyamines, small molecules found in all cells. "Polyamines are usually considered 'good guys,' because they have been shown to protect DNA from oxidative damage," says Dr. Brooks. Yet the researchers found the polyamines facilitated the conversion of acetaldehyde into crotonaldehyde (CrA), an environmental pollutant that has been shown to cause cancer in animals. This chemical in turn altered DNA, generating an abnormal, mutagenic DNA base called a Cr-PdG adduct. Dr. Brooks says, "We concluded that polyamines stimulated the formation of Cr-PdG adducts from acetaldehyde, and this may provide a mechanism to explain how alcohol consumption increases the risk of some types of cancer."
Previous studies had shown acetaldehyde could be converted
Contact: Gregory Roa
NIH/National Institute on Alcohol Abuse and Alcoholism