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Finding of a new molecular marker of resistance to chemotherapy in breast cancer

A collaborative study between the Hospital Clnic and the Hospital del Mar de Barcelona permits to establish a predictive factor in the resistance to chemotherapy in breast cancer and to establish possible therapeutic targets for the improvement of this treatment. This study has been published this month in the journal Endocrine-Related Cancer and is the result of the work initiated by Dr. Albanell's Group in Hospital Clnic, and finished in Hospital del Mar, where he leads the Unit of Oncology since almost a year. From the beginning, this study had the participation of the Unit of Pathology and Oncology of Hospital del Mar, and the Unit of Research on Cancer Experimental Therapeutics of Hospital del Mar-IMIM.

This study shows clinical evidence of the role played by the nuclear factor (NF)-ĸB in breast cancer and makes it a key target for new treatments, both to be aware of its existence and to predict a low chemotherapy response. If this is the case, the blocking of the factor prior to treatment is needed in order to increase the efficiency of treatment. The results of this study are the first to be published in which nuclear factor (NF)-ĸB, which promotes the survival of cells, has been specifically studied in order to observe its relevance in the prediction of response to chemotherapy.

Breast cancer is the most frequent cancer among women around the globe, with more than one million cases every year. It is the first cause of lost of potential years of life, and the second leading cause of cancer death among women. Breast cancer is one of the diseases causing more disorders to women in the developed countries because of the increase of new cases, its high mortality and the social repercussion it entails.

In Catalonia, the prevalence of breast cancer is of more than 50,000 women. Although the number of cases and incidence rate increase every year, mortality rate decreases. Survival of patients is improvin
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Contact: Rosa Manaut, Communication Hospital del Mar, Barcelona
rmanaut@imas.imim.es
34-618-509-885
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
28-Jun-2006


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