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Finding of a new molecular marker of resistance to chemotherapy in breast cancer

g, achieving a 5 year survival of almost 80%, a number higher than the European mean. The improvement of the screening programmes and the continuous improvements in treatment underlie the key of success in the decrease of mortality. Chemotherapy treatment plays an important role in recovery or increase of survival of these patients. Now, a new line to improve results consists in finding which patients are benefited from chemotherapy in order to make a personalized treatment.

The study and its impact

This study has contributed to the understanding of one of the resistance mechanisms to chemotherapy previous to surgery in patients of locally advanced breast cancer. If the response to preoperational chemotherapy is improved, not only survival improves, but also surgeries can be less radical, preservation of the breast is possible and decrease the psychological, emotional and social impact of the treatment is achieved.

"Results show that patients with breast cancer who presented activated nuclear factor (NF)-ĸB in tumour cells prior to treatment with chemotherapy, only achieve 20% response to chemotherapy", explains Dr. Tusquets, "whereas if (NF)-ĸB is not activated, chemotherapy response increases up to 91%". Moreover, the relevance of this factor has been confirmed since the activation of (NF)-ĸB increases after chemotherapy exposure, what could explain part of the acquired chemotherapy resistance during treatment.

The repercussion of this study and the fact that it confirms clinically other cellular results permits to consider this study as a departure point for future studies regarding this factor in collaboration with other hospitals, and to be able to offer personalized treatments in the future. "Not only can we predict chemotherapy response of tumour before treatment is started, but also can we search for a mechanism to act upon the nuclear factor (NF)-ĸB, deactivate it and
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Contact: Rosa Manaut, Communication Hospital del Mar, Barcelona
rmanaut@imas.imim.es
34-618-509-885
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
28-Jun-2006


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