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Finding protection from tumor growth in unexpected places

e immune response and convey protection as direct injection of these cells into melanoma tumors of normal mice yielded decreased tumor size.

Together these studies provide strong evidence that high ACE expression in macrophages produces strong anti-tumor activity. In addition, while most of these studies were performed with melanoma cells, similar results were also obtained with lymphoma cells, demonstrating that ACE-expressing macrophages hold great promise for other forms of cancer. As stated by Shen et al, If ACE 10/10 mice define a general yet simple means of enhancing immunity, this may be useful to human tumor therapy as well as in other clinical settings.


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Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
5-Jun-2007


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