HOME >> BIOLOGY >> NEWS
Findings by Einstein scientists reveal possible strategy against obesity, diabetes and infertility

(BRONX, NY) Twelve years ago, scientists discovered leptin--the now-famous hormone that controls appetite, burns calories and performs other crucial physiological activities as well. But the precise mechanism(s) by which leptin carries out these metabolic tasks is still controversial. Now, researchers at the Albert Einstein College of Medicine of Yeshiva University have shown how leptin exerts some of its most important effects.

Their findings, reported in the July 5 issue of Cell Metabolism, suggest a novel approach for duplicating leptin's actions when the body no longer responds to the hormone.

Fat cells release leptin into the bloodstream. The hypothalamus "reads" the amount of circulating leptin and uses this information to regulate appetite, metabolism and other processes. "Leptin is known to bind to cell-surface receptors in the hypothalamus and then to activate various other cellular signals including a molecule called STAT3--but the role of STAT3 in mediating leptin's multiple physiological effects was still unknown," says Dr. Luciano Rossetti, the study's senior author and the director of the Diabetes Research and Training Center at Einstein.

To learn whether STAT3 mediates some of leptin's activities, "we devised a technique for inactivating STAT3 with pinpoint accuracy in the hypothalamus and observing the results in laboratory animals when we administered leptin," says Dr. Rossetti. "Our tool for rapidly inactivating STAT3 was a cell-permeable peptide (short protein) that we infused into specific areas of the hypothalamus using fine needles. This technique can serve as a model for investigating all types of signaling pathways in selective regions of the brain."

The researchers found that STAT3 production is essential for leptin's best-known action: acutely reducing food intake. Since obesity occurs when people become resistant to leptin's "curb your eating" message, this finding suggests that bypassing leptin and
'"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
5-Jul-2006


Page: 1 2

Related biology news :

1. Findings on plummeting salmon populations at 8th World Wilderness Congress
2. Findings suggests that blocking estrogen may be crucial to lung cancer survival
3. Findings show how toxic proteins rob Alzheimers patients of memory
4. Findings challenge Darwinian theory
5. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
6. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
7. Einstein researchers discover radiation-eating fungi
8. Einsteins Dr. Vern Schramm elected to the National Academy of Sciences
9. Einstein researchers discover how a key dietary vitamin is absorbed
10. NCI funds Einstein and U. Albany NanoCollege to make worlds smallest cancer detection device
11. Team at CNSE and Einstein receive grant to develop worlds smallest cancer detection device

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... ... 28, 2020 , ... Ever a responsive and supportive partner ... and critical information to life science organizations as they navigate the ever-changing economic ... “Providing the most up-to-date actionable guidance and information has been a keystone of ...
(Date:4/28/2020)... FT. LAUDERDALE, Fla. (PRWEB) , ... April 27, ... ... official launch. The first-of-its-kind category-defining service was started by three teenagers with an ... a change in the world during the time of great need and suffering, ...
(Date:4/26/2020)... NEW YORK (PRWEB) , ... April 23, 2020 , ... ... collaboration with GenScript, is developing a synthetic antibody to SARS-CoV-2, the virus that causes ... lung cells, and would be another potential treatment option for COVID-19. , The efforts ...
Breaking Biology News(10 mins):
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. announced the ... and services for use on Microsoft Azure. The customer experience management (CXM) technology ... for a built-for-purpose customer engagement capability to use in their commercial or medical ...
(Date:4/22/2020)... ... April 21, 2020 , ... ... method for determination of FXIII. , Aniara Diagnostica, a multi-national distributor of diagnostic ... meeting today’s highest standards for product quality and cost-efficient delivery. , ...
(Date:4/7/2020)... ... April 06, 2020 , ... Gateway Genomics , leading developer of ... SneakPeek Early Gender DNA Tests sold in March, just months after attaining the ... ecommerce product, where a mom could order her kit online, collect a DNA sample ...
(Date:4/1/2020)... ... March 30, 2020 , ... A joint venture ... (RID), formed earlier this year to bring telehealth to various government agencies, has ... COVID-19. Company officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from the ...
Breaking Biology Technology:
Cached News: