HOME >> BIOLOGY >> NEWS
First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines

The first genome-wide association study of an infectious disease, conducted by an international group of researchers through the Center for HIV/AIDS Vaccine Immunology (CHAVI), has yielded a new understanding of why some people can suppress virus levels following HIV infection. The clearer picture of host responses to the virus achieved through this examination of genomes could lead to improved HIV therapies and provides new targets for vaccine developers, says Elias A. Zerhouni, M.D., director of the National Institutes of Health (NIH). CHAVI, which is led by Barton Haynes, M.D., of Duke University, Durham, N.C., was established in 2005 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH.

CHAVIs host genetics team, led by David Goldstein, Ph.D., also of Duke University, included scientists from several European countries and Australia who formed a consortium, EuroCHAVI, to perform this study. The investigators identified three gene variants, two of which are linked to an infected persons ability to control HIV viral load and a third that is implicated in disease progression to AIDS. The research is being published by Science on the Science Express Web site on Thursday, July 19.

CHAVI is designed to foster collaborative research to overcome roadblocks that have impeded HIV vaccine development, says NIAID Director Anthony S. Fauci, M.D. The insights into genetic factors influencing host control of HIV revealed by this work exemplify the power of such collective investigations.

Genome-wide association studies aim to identify genetic variations among people that can be tied to variations in disease susceptibility. Recent genome-wide association studies have found genetic markers linked to increased risk of such ailments as diabetes, cancer and heart disease. The CHAVI investigators are the first to apply genome-wide association techniques to an infectious disease.

People vary greatly in thei
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
19-Jul-2007


Page: 1 2 3

Related biology news :

1. First case of successful ovarian tissue transplantation between two, nonidentical sisters
2. First new multiple sclerosis gene found in 30 years
3. First all-African produced genetically engineered maize is resistant to maize streak virus
4. First baby is born after oocytes were matured in the lab and frozen
5. First confirmed common genetic risk factors for breast cancer
6. First demonstration of new hair follicle generation in an animal model
7. First research to show that diabetes damages DNA in mens sperm and may affect fertility
8. First demonstration of muscle restoration in an animal model of Duchenne muscular dystrophy
9. First systematic study of Chinas one-child policy reveals complexity, effectiveness
10. First international conference on self-healing materials
11. First impressions: Computer model behaves like humans on visual categorization task

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... ... from nonprofit U.S. universities and research institutions for its Instrumentation Grant for ... up to $1.2 million per site for the acquisition of instrumentation, development and ...
(Date:11/9/2019)... ... November 08, 2019 , ... StageBio ... histology, pathology, biomarker development, and archiving services for the biopharmaceutical, medical device ... Histo-Scientific Research Laboratories (HSRL), Vet Path Services (VPS) and Tox Path Specialists ...
(Date:11/6/2019)... ... November 06, 2019 , ... Genomenon® ... Engine now includes the ability to search the entirety of the genomic literature ... genetic and rare diseases. , Patients, particularly those with rare diseases, don’t always ...
Breaking Biology News(10 mins):
(Date:10/15/2019)... ... ... ARPR , an award-winning tech PR agency at the epicenter of the future of ... of the Year in the Ragan’s Health Care PR & Marketing Awards. This award marks ... also revealed today that its healthIT practice group grew by 18 percent in Q3 this ...
(Date:10/10/2019)... ... October 09, 2019 , ... As World ... middle school and high school students have improved neuro-cognitive executive skills to enhance ... physical fitness, and apply lifelong social/interpersonal, leadership, problem-solving and coping skills, due to ...
(Date:10/10/2019)... ... October 10, 2019 , ... ... of clinical research centers in Europe. All Pratia research centers have completed VirTrial’s ... become trained and certified as Virtual Trial Capable and prepared to conduct decentralized ...
(Date:10/8/2019)... MELBOURNE, Fla. (PRWEB) , ... October 07, 2019 ... ... and development of low level laser therapy technology (“3LT®”), today announces that the ... to market its EVRL low level laser for the temporary relief of chronic ...
Breaking Biology Technology:
Cached News: