HOME >> BIOLOGY >> NEWS
First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines

The first genome-wide association study of an infectious disease, conducted by an international group of researchers through the Center for HIV/AIDS Vaccine Immunology (CHAVI), has yielded a new understanding of why some people can suppress virus levels following HIV infection. The clearer picture of host responses to the virus achieved through this examination of genomes could lead to improved HIV therapies and provides new targets for vaccine developers, says Elias A. Zerhouni, M.D., director of the National Institutes of Health (NIH). CHAVI, which is led by Barton Haynes, M.D., of Duke University, Durham, N.C., was established in 2005 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH.

CHAVIs host genetics team, led by David Goldstein, Ph.D., also of Duke University, included scientists from several European countries and Australia who formed a consortium, EuroCHAVI, to perform this study. The investigators identified three gene variants, two of which are linked to an infected persons ability to control HIV viral load and a third that is implicated in disease progression to AIDS. The research is being published by Science on the Science Express Web site on Thursday, July 19.

CHAVI is designed to foster collaborative research to overcome roadblocks that have impeded HIV vaccine development, says NIAID Director Anthony S. Fauci, M.D. The insights into genetic factors influencing host control of HIV revealed by this work exemplify the power of such collective investigations.

Genome-wide association studies aim to identify genetic variations among people that can be tied to variations in disease susceptibility. Recent genome-wide association studies have found genetic markers linked to increased risk of such ailments as diabetes, cancer and heart disease. The CHAVI investigators are the first to apply genome-wide association techniques to an infectious disease.

People vary greatly in thei
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
19-Jul-2007


Page: 1 2 3

Related biology news :

1. First case of successful ovarian tissue transplantation between two, nonidentical sisters
2. First new multiple sclerosis gene found in 30 years
3. First all-African produced genetically engineered maize is resistant to maize streak virus
4. First baby is born after oocytes were matured in the lab and frozen
5. First confirmed common genetic risk factors for breast cancer
6. First demonstration of new hair follicle generation in an animal model
7. First research to show that diabetes damages DNA in mens sperm and may affect fertility
8. First demonstration of muscle restoration in an animal model of Duchenne muscular dystrophy
9. First systematic study of Chinas one-child policy reveals complexity, effectiveness
10. First international conference on self-healing materials
11. First impressions: Computer model behaves like humans on visual categorization task

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/29/2018)... (PRWEB) , ... July 29, 2018 , ... Dr. William ... biofield energy treated nutraceutical to improve overall immunity and to combat inflammation and autoimmune ... well as inflammation. The following data was reported:, Up ...
(Date:7/28/2018)... (PRWEB) , ... July 28, 2018 , ... ... at The Hong Kong Polytechnic University (PolyU), has been honoured with the International ... to the field of wind engineering and bridge engineering in research, education, and ...
(Date:7/26/2018)... ... July 25, 2018 , ... ... C-level biopharma executives on September 4, 2018 at The Hilton Boston Back Bay ... from real-life business development experiences and dissect the most relevant deals in biotech. ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative veterinary medicine ... extracting and using adipose tissue-derived stem cells to treat or prevent inflammation at ... patent covers Canada specifically, VetStem has been issued similar patents that cover the ...
(Date:7/27/2018)... ... July 27, 2018 , ... ... Advocacy Group (BRAG®) and representatives of the Biotechnology Innovation Organization (BIO) met ... recently-issued white paper, “Proposal for a Toxic Substances Control Act (TSCA) Inventory ...
(Date:7/25/2018)... ... July 25, 2018 , ... Dimitrius ... proprietary nutraceutical to combat inflammation and autoimmune disorders. , The preclinical research ... The following data was reported:, Over 70% decrease ...
(Date:7/25/2018)... , ... July 25, 2018 , ... ... for managing clinical trial patient and supplies data through its flagship IXRS® ... on IRT: Best Practices.” , This podcast features both Almac thought leaders and ...
Breaking Biology Technology:
Cached News: