First step towards a non-invasive screening test for early signs of testicu...( Dr Hoei-Hansen said that if the test wa...)

First step towards a non-invasive screening test for early signs of testicular cancer

Dr Hoei-Hansen said that if the test was to be offered more widely, some parts of the analysis would be handled automatically and more efficiently. "We believe the method would be relatively inexpensive," she said.

Amongst the first 104 patients included in the study, the test detected testicular cancer in 5 out of 12 men with testicular cancer, and when the control patient with CIS was added, this meant the test had a sensitivity of 46%. There were no false-positives, which suggested that the test was highly specific.

Dr Hoei-Hansen said: "The large proportion of negative results in the testicular cancer patients could be due to the small volume of the semen sample used for the test 50-300 microlitres out of a total normal volume of 3-5 millilitres thus stressing the need for either repeated analysis or larger volumes analysed. These conditions will be assessed in an ongoing study of a larger number of patients. Negative results could also be due to compression from the tumour obstructing tubules, resulting in few or no CIS cells being shed into semen." However, she said she was pleased with the sensitivity of this early study.

Prof Skakkebk concluded: "If further studies confirm that this method could be used as a simple, non-invasive screening test, it could be offered in andrology and fertility clinics to young men at risk of testicular cancer because of atrophic testes, a history of cryptorchidism or who need assisted reproduction techniques. The real advantage would be that young men could be diagnosed at the pre-invasive stage of testicular cancer, when the disease had not metastasised, when only surgery would be required, and not radio- or chemotherapy. With this more gentle treatment, fertility is usually unaffected."

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Contact: Emma Mason
wordmason@mac.com
44-1-376-563-090
European Society for Human Reproduction and Embryology
2-Mar-2005

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