HOME >> BIOLOGY >> NEWS
Fish and chips: A fast track to understanding blood development

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology. In the paper, Catherine Verfaillie and colleagues identify 277 human genes with different gene expression profiles in stem and progenitor cells involved in blood cell development, or hematopoiesis. The paper also suggests that a developmental regulator called fibroblast growth factor may play a role in hematopoiesis.

The new method may also have relevance beyond the field of blood development. "This could be done not only for hematopoietic stem cells as is done here but also for brain, pancreas, endothelium, smooth and cardiac muscle, because of the high homology between man and fish in development of these tissues," explains Verfaillie.

The RNA transcript microarray, or "RNA chip," allowed Verfaillie and colleagues to compare gene expression in cell cultures with many or few hematopoietic stem cells. Previously, the authors had developed a method to harvest stem cells using bone marrow and blood from umbilical cords. Sixty-one of the 277 genes found to have different expressions profiles in stem and progenitor cells had no known function in human hematopoietic stem cells, though the genes do resemble genes found in zebrafish. Fish with mutated versions of fourteen of these genes developed blood disorders, suggesting that the genes are necessary for normal hematopoiesis. Three of the 14 genes are known to play a role in fibroblast growth factor signaling. In the future, researchers may learn the specific relationship between fibroblast growth factor and hematopoiesis.

But Verfaillie stresses that the study has implications for researchers in various fields. "This is one of the first examples in the literature where high-throughput gene expression analysis using gene arrays has been functionally validated by
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
4-Jul-2005


Page: 1 2

Related biology news :

1. Satellite tracking reveals threats to Borneo pygmy elephants
2. Satellite tracking will help answer questions about penguin travels
3. Species detectives track unseen evolution
4. Better sleep may put Huntingtons disease sufferers back on track
5. Biovest announces interim blinded data of fast-tracked pivotal Phase 3 clinical trial of BiovaxID
6. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
7. Researchers track snakes to study populations, behavior
8. Researchers track how spores break out of dormant state
9. Salmon tracking program expands to California
10. Simple equations track Listeria trails
11. Bat flight generates complex aerodynamic tracks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... Vigilant Solutions announces today that an agency used its Vigilant ... in a difficult homicide case. The agency then used Vigilant,s ... vehicle. Due to the ongoing investigation, the agency name and ... agency,s request. --> --> ... deceased at an intersection here in the City. He had ...
(Date:2/4/2016)... -- The field of Human Microbiome research and ... hubs of the biotechnology industry. While the Human ... human microbiota, have garnered a lot of attention ... has literally exploded in terms of both basic ... on biomedical aspects of research, development, and commercial ...
(Date:2/3/2016)... Calif. , Feb. 3, 2016 Vigilant ... Police Department in Missouri ... license plate reader (LPR) data from Vigilant Solutions. ... hit-and-run case in which the victim was walking out of a convenience ... parking space next to his vehicle, striking his vehicle ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... NY (PRWEB) , ... February 10, 2016 , ... LATHAM, ... packages at the SPIE Photonics West conference in San Francisco’s Moscone Center ... 14 in the same venue. , These latest InGaAs PIN diode standard packages ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... medicine, has announced a new agreement with Singapore-based Global Stem Cells Network (GSCN) ... the Philippines, Thailand and Singapore in the latest adipose and bone marrow therapies. ...
(Date:2/9/2016)... N.J. , Feb. 9, 2016  Regenicin, ... biotechnology company specializing in the development and commercialization ... of damaged tissues and organs, recently reported the ... the first quarter of 2016. Lonza ... the new 2015 fiscal year in the process ...
(Date:2/9/2016)... ... , ... Tunnell Consulting, Inc. announced that Frédéric Lefebvre has joined the firm ... new accounts and work closely with existing Tunnell clients throughout Europe to ensure their ... clients more than 15 years of experience in the pharmaceutical industry, a thorough knowledge ...
Breaking Biology Technology:
Cached News: