HOME >> BIOLOGY >> NEWS
Fish and chips: A fast track to understanding blood development

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology. In the paper, Catherine Verfaillie and colleagues identify 277 human genes with different gene expression profiles in stem and progenitor cells involved in blood cell development, or hematopoiesis. The paper also suggests that a developmental regulator called fibroblast growth factor may play a role in hematopoiesis.

The new method may also have relevance beyond the field of blood development. "This could be done not only for hematopoietic stem cells as is done here but also for brain, pancreas, endothelium, smooth and cardiac muscle, because of the high homology between man and fish in development of these tissues," explains Verfaillie.

The RNA transcript microarray, or "RNA chip," allowed Verfaillie and colleagues to compare gene expression in cell cultures with many or few hematopoietic stem cells. Previously, the authors had developed a method to harvest stem cells using bone marrow and blood from umbilical cords. Sixty-one of the 277 genes found to have different expressions profiles in stem and progenitor cells had no known function in human hematopoietic stem cells, though the genes do resemble genes found in zebrafish. Fish with mutated versions of fourteen of these genes developed blood disorders, suggesting that the genes are necessary for normal hematopoiesis. Three of the 14 genes are known to play a role in fibroblast growth factor signaling. In the future, researchers may learn the specific relationship between fibroblast growth factor and hematopoiesis.

But Verfaillie stresses that the study has implications for researchers in various fields. "This is one of the first examples in the literature where high-throughput gene expression analysis using gene arrays has been functionally validated by
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
4-Jul-2005


Page: 1 2

Related biology news :

1. Satellite tracking reveals threats to Borneo pygmy elephants
2. Satellite tracking will help answer questions about penguin travels
3. Species detectives track unseen evolution
4. Better sleep may put Huntingtons disease sufferers back on track
5. Biovest announces interim blinded data of fast-tracked pivotal Phase 3 clinical trial of BiovaxID
6. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
7. Researchers track snakes to study populations, behavior
8. Researchers track how spores break out of dormant state
9. Salmon tracking program expands to California
10. Simple equations track Listeria trails
11. Bat flight generates complex aerodynamic tracks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Fish and chips fast track understanding blood development

(Date:5/8/2015)... 8, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... members of the executive management team will present at the ... Media and Telecom Conference Date: May 18, 2015 ... Boston, MA Cowen and Company Technology, ... ET Location: The New York Palace Hotel, New ...
(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
(Date:5/28/2015)... 28, 2015 BioNorth Texas (BioNorthTX), ... representing the life sciences industry in northern region ... meeting at The Foundry in Dallas on April ... brought together a broad spectrum of biotech professionals ... organization's early successes in partnering with key life ...
(Date:5/28/2015)... and London (PRWEB) May 28, 2015 ... of Computer Aided Engineering software, announced today it ... Inc. (PSRI). CD-adapco will provide state-of-the-art engineering simulation ... will share their expertise and experiences in analyzing ... refining industry members and advance the understanding of ...
(Date:5/28/2015)... Atlanta, Georgia (PRWEB) May 28, 2015 ... Ridge National Laboratory (Oak Ridge, TN) recently ... strength of 3D printing plastic resins using nanocellulose, ... well-known constraint of 3D printing is the limited ... resins provide inadequate mechanical strength to printed parts ...
(Date:5/27/2015)... MARLBOROUGH, Mass. , May 27, 2015 /PRNewswire/ ... a biotechnology company focused on discovering and developing ... and ophthalmology, today announced that it has commenced a ... warrants to purchase shares of its common stock ... its common stock. The shares of common stock, ...
Breaking Biology Technology:BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3
Cached News: