HOME >> BIOLOGY >> NEWS
Fleshing out the genome

SEATTLE Genomics, the study of all the genetic sequences in living organisms, has leaned heavily on the blueprint metaphor. A large part of the blueprint, unfortunately, has been unintelligible, with no good way to distinguish a bathroom from a boardroom, to link genomic features to cell function.

A national consortium of scientists led by BIATECH, a Seattle based non-profit research center, and Pacific Northwest National Laboratory (PNNL), a Department of Energy research institution in Richland, Wash., now suggests a way to put this house in order. They offer a powerful new method that integrates experimental and computational analyses to ascribe function to genes that had been termed "hypothetical" -- sequences that appear in the genome but whose biological purposes were previously unknown.

The method not only portends a way to fill in the blanks in any organism's genome but also to compare the genomes of different organisms and their evolutionary relationship.

The new tools and approaches offer the most-comprehensive-to-date "functional annotation," a way of assigning the mystery sequences biological function and ranking them based on their similarity to genes known to encode proteins. Proteins are the workhorses of the cell, playing a role in everything from energy transport and metabolism to cellular communication.

This new ability to rank hypothetical sequences according to their likelihood to encode proteins "will be vital for any further experimentation and, eventually, for predicting biological function," said Eugene Kolker, president and director of BIATECH, an affiliate scientist at PNNL and lead author of a study in the Feb. 8 Proceedings of the National Academy of Sciences that applies the new annotation method to a strain of the metal-detoxifying bacterium Shewanella oneidensis.

"In a lot of cases," said James K. Fredrickson, a co-author and PNNL chief scientist, "it was not known from the gene sequence if a
'"/>


3-Feb-2005


Page: 1 2

Related biology news :

1. Unravelling new complexity in the genome
2. One species, many genomes
3. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
4. Charting ever-changing genomes
5. Neutral evolution has helped shape our genome
6. Sea anemone genome provides new view of our multi-celled ancestors
7. Cloning the male genome may help infertile men
8. Mutating the entire genome
9. Exploring the dark matter of the genome
10. New findings challenge established views on human genome
11. ENCODE map changes view of the human genome landscape

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... April 17, 2019 , ... USDM Life Sciences (USDM) announces that Jay Crowley, ... solutions for Creating a Sustainable Global UDI Compliance Strategy at the European UDI Forum ... , What device manufacturers did to comply with the US FDA UDI ...
(Date:4/16/2019)... Texas (PRWEB) , ... April 16, 2019 , ... ... collaboration between employers and search firms with over $2 billion in placement fees ... with applicant tracking and employee onboarding platform, ExactHire. , This strategic relationship ...
(Date:4/16/2019)... (PRWEB) , ... April 16, 2019 , ... ... its featured speakers for two signature events: The 2019 ISPE Biopharmaceutical Manufacturing ... on 20–21 June. Taking place in one of the most influential bio ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... USDM ... capacity of life sciences organizations to accelerate innovation and maximize productivity, announces that ... the past 12 months. , USDM’s Cloud Assurance is a managed ...
(Date:4/9/2019)... (PRWEB) , ... April 09, 2019 , ... The ... incoming members of the Society's leadership team, including a new addition to the presidential ... five of their peers to join the Society's leadership team for a three-year term ...
(Date:4/8/2019)... ... 2019 , ... US Capital Global Securities , an affiliate of US ... the privately held pharmaceutical company, S1 Biopharma (“S1”). , S1 has a pipeline of ... sexual dysfunction disorder and is ready to begin phase 2b trials. In phase 2a ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, Inc. , a ... latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal tests called ... Rosland Franklin, an English chemist and X-ray crystallographer who made significant contributions to ...
Breaking Biology Technology:
Cached News: