HOME >> BIOLOGY >> NEWS
Fleshing out the genome

SEATTLE Genomics, the study of all the genetic sequences in living organisms, has leaned heavily on the blueprint metaphor. A large part of the blueprint, unfortunately, has been unintelligible, with no good way to distinguish a bathroom from a boardroom, to link genomic features to cell function.

A national consortium of scientists led by BIATECH, a Seattle based non-profit research center, and Pacific Northwest National Laboratory (PNNL), a Department of Energy research institution in Richland, Wash., now suggests a way to put this house in order. They offer a powerful new method that integrates experimental and computational analyses to ascribe function to genes that had been termed "hypothetical" -- sequences that appear in the genome but whose biological purposes were previously unknown.

The method not only portends a way to fill in the blanks in any organism's genome but also to compare the genomes of different organisms and their evolutionary relationship.

The new tools and approaches offer the most-comprehensive-to-date "functional annotation," a way of assigning the mystery sequences biological function and ranking them based on their similarity to genes known to encode proteins. Proteins are the workhorses of the cell, playing a role in everything from energy transport and metabolism to cellular communication.

This new ability to rank hypothetical sequences according to their likelihood to encode proteins "will be vital for any further experimentation and, eventually, for predicting biological function," said Eugene Kolker, president and director of BIATECH, an affiliate scientist at PNNL and lead author of a study in the Feb. 8 Proceedings of the National Academy of Sciences that applies the new annotation method to a strain of the metal-detoxifying bacterium Shewanella oneidensis.

"In a lot of cases," said James K. Fredrickson, a co-author and PNNL chief scientist, "it was not known from the gene sequence if a
'"/>


3-Feb-2005


Page: 1 2

Related biology news :

1. Unravelling new complexity in the genome
2. One species, many genomes
3. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
4. Charting ever-changing genomes
5. Neutral evolution has helped shape our genome
6. Sea anemone genome provides new view of our multi-celled ancestors
7. Cloning the male genome may help infertile men
8. Mutating the entire genome
9. Exploring the dark matter of the genome
10. New findings challenge established views on human genome
11. ENCODE map changes view of the human genome landscape

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2018)... ... , ... Mandy is an eight-year-old mini Australian shepherd and a tripod. When Mandy was four ... three surgeries to try to repair the leg and each time it was unsuccessful. ... owner, along with her veterinarian, decided to amputate. With only one front leg, mobility ...
(Date:8/23/2018)... DIEGO (PRWEB) , ... August 22, 2018 , ... Lajollacooks4u is proud to have hosted ... second or third time. Companies, such as Illumina, Qualcomm, Hewlett Packard, Sequenom and more, ... bond with their teams. , Part of the reason clientele return is due ...
(Date:8/21/2018)... ... 21, 2018 , ... Whether it be online or through ... offering customers a successful experience. When browsing the new site in search ... with relevant details such as technical manuals, application notes, and instrument compatibility readily ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... (PRWEB) , ... September 11, 2018 , ... ... at the American Association of Feline Practitioners Conference (AAFP) later this ... data on adipose-derived stem cell therapy for the treatment of chronic kidney disease ...
(Date:9/12/2018)... Va. (PRWEB) , ... September 12, 2018 , ... ... Lauren Bronich-Hall, a quality management professional and former Senior Director of Regulatory Affairs ... Consultant. , As Senior Director of Regulatory Affairs and Quality Systems at ...
(Date:9/7/2018)... ... September 06, 2018 , ... ... September 25th-28th is a meeting of “The industry’s preeminent event on novel drug ... discovery scientists powerful tools to study these emerging targets in a quest to ...
(Date:9/7/2018)... Colo. (PRWEB) , ... September 06, 2018 , ... ... DMD, a fatal neuromuscular disease, has been validated to be as effective as ... Assessment of Dystrophin Staining in Frozen Muscle Biopsies,” was published in the Archives ...
Breaking Biology Technology:
Cached News: