HOME >> BIOLOGY >> NEWS
Flu shot effective against drifted influenza, nasal spray vaccine less so

ANN ARBOR, Mich.--- During a year in which the circulating strains of influenza showed genetic differences from the strains in vaccines, the traditional killed-virus flu shot was found to be effective in preventing influenza in healthy adults. The live attenuated-virus nasal spray vaccine also prevented illnesses but was less effective.

Both outcomes were determined by laboratory confirmation of flu infection, a University of Michigan study found.

Earlier studies had suggested that the nasal spray, sold by MedImmune as FluMist, might offer better protection against drifted viruses that had genetically changed between vaccine formulation and annual influenza activity. The nasal spray, which is based on a live but weakened virus, was 86 percent protective in one study conducted in children during a major drift year. However, FluMist had not previously been studied head-to-head against the shot in adults with laboratory confirmation.

The killed-virus flu shot is usually billed as 70 to 90 percent effective against circulating strains that are well matched to vaccine strains. During the 2004-2005 flu season, a University of Michigan team found that the killed-virus flu shot was 75 percent effective against a moderately-drifted type A virus and two types of B virus. The standard formulation of both the flu shot and the nasal spray vaccine includes two types of A influenza and one B, but in the 2004-05 season, there were two B strains circulating and one type A.

"On the other hand, FluMist was 48 percent effective. These results may only apply to the 2004-05 flu season," said Dr. Arnold S. Monto, professor of epidemiology. "In other years the results may be different. We need a more specific understanding of which viral changes matter and which don't. There are many things about vaccine protectiveness that we still don't completely understand."

"It may be that the difference in effectiveness between the shot and the spray c
'"/>

Contact: Karl Leif Bates
batesk@umich.edu
734-647-1842
University of Michigan
13-Dec-2006


Page: 1 2 3

Related biology news :

1. Smokeless tobacco more effective than cigarettes for delivering dangerous carcinogens into the body
2. Developing a more effective vaccine for tuberculosis
3. Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
4. Implanon, Norplant and Jadelle are all effective contraceptives -- but side effects vary
5. High blood pressure medication strategy proves effective in Hispanic women
6. New compound effectively treats fungal infections
7. Northern forests less effective than tropical forests in reducing global warming
8. Cisplatin is more effective than carboplatin for treating nonsmall cell lung cancer
9. Scientists develop new drugs to fight colon and breast cancer more effectively
10. Avian influenza survivors antibodies effective at neutralising H5N1 strain
11. Studies assess effectiveness of serotonin and nerve stimulants on irritable bowel syndromes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/18/2020)... ... 2020 , ... Commercial launch readiness is a critical stage in a product ... or vaccine, the global economic downturn will only increase price pressures overall for the ... capturing full value from every product launch is critical. However, history shows that only ...
(Date:7/2/2020)... CITY, Calif. (PRWEB) , ... July 01, 2020 ... ... biotech company, presented its phase 1a findings of Neihulizumab, a biologic for the ... conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of the ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... solutions for biopharmaceutical R&D, today announced that it has entered into a ... multispecific antibodies (Multiclonics®), to support their translational and clinical research strategy to ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its platform ... Biologics since its formation in 2016, the company is relaunching itself under the Ardent ... its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of this ... around the globe, requiring fast track capacity to provide patients with urgently needed ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
Breaking Biology Technology:
Cached News: