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Folate and B12 may influence cognition in seniors

and high serum folate was the worst combination," says Morris. "Specifically, anemia and cognitive impairment were observed nearly five times as often for people with this combination than among people with normal vitamin B12 and normal folate." Vitamin B12 deficiency, which affects many seniors due to age-related decreases in absorption, can impact the production of DNA needed for new cells, as well as neurological function.

Vitamin B12 is normally consumed in meat, fish, poultry, eggs, and dairy products, and folate is found in leafy green vegetables, citrus fruits, and beans. Although folate occurs naturally in many foods, the U.S. Food and Drug Administration in 1998 required that all enriched cereal-grain products be fortified with folic acid, the synthetic form of folate, in order to help prevent birth defects in infants.

Morris notes that the study's results are inconsistent with the idea that high folate status delays detection of vitamin B12 by masking one of its key signs: anemia. "When folate fortification was considered, opponents raised the possibility that because more folate might mask anemia, many cases of vitamin B12 deficiency would go undetected, causing people with the condition to suffer neuropsychiatric consequences. But in our study, the people with low vitamin B12 who also had high serum folate were more likely to exhibit anemia and cognitive impairment than subjects with low vitamin B12 status and normal serum folate. So although having high serum folate had an impact on cognitive function in our study, it did not cure anemia, as opponents of food fortification have suggested."

Senior author Jacob Selhub, PhD, director of the Vitamin Metabolism Laboratory at the USDA HNRCA and professor at the Friedman School, says, "Our findings support the often-expressed idea that many seniors would benefit from more folate, but the research shows that we must look at the effects this would have on seniors with age-related v
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Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University
9-Feb-2007


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