HOME >> BIOLOGY >> NEWS
Forsyth scientists gain new understanding of adult stem cell regulation

Forsyth Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages that control stem cell regulation such as the message that maintain and tells a stem cell to specialize and to become part of an organ e.g.: liver or skin.

In recent years, planarians have been recognized as a great model system to molecularly dissect conserved stem cell regulatory mechanisms in vivo. Planarians have powerful regeneration capability that makes them ideal for studying this process. The Forsyth team uses planarians and other animal models to study development and regeneration.

The Forsyth team will publish this research in the August 16 issue of Development. According to the papers lead author, Nstor J. Oviedo, a postdoctoral fellow in the Forsyth Center for Regenerative and Developmental Biology, this work, highlighting the importance of direct cell-cell transfer of small molecules between stem cells and their neighbors, provides an important roadmap for learning about regeneration. These findings suggest that similar mechanisms may be extraordinarily relevant for controlling the behavior of migratory, plastic cells. Further analysis in both planarians and in vertebrates will provide crucial opportunities for understanding what drives stem cell behavior and may help medical science identify novel therapeutic targets.

The Forsyth team previously found that communication through gap-junctions (microscopic tunnels directly linking neighboring cells) controls the left-right asymmetric positioning of the internal organs during embryonic development. In this study, they turned to the role of gap junctional signals as regulators of adult stem cells in repair of injury.

Drs. Oviedo and Levin focused
'"/>

Contact: Jennifer Kelly
jkelly@forsyth.org
617-892-8602
Forsyth Institute
1-Aug-2007


Page: 1 2

Related biology news :

1. Forsyth scientists discover early key to regeneration
2. Forsyth scientists find linkages between serotonin reuptake inhibitors and bone mass
3. Forsyth scientists develop system for automated analysis of behavior
4. Forsyth issues imperative for a vaccine against cavities
5. Forsyth scientists gain greater understanding of how embryos differentiate left from right
6. New understanding of regeneration gained by Forsyth scientists
7. Forsyth scientists identify a gene responsible for facial diversity
8. Forsyth scientists find three bacteria associated with oral cancer
9. Brain chemical serotonin involved in early embryo patterning, Forsyth scientists find
10. Forsyth scientists find blue light fights gum disease culprits
11. UK scientists working to help cut ID theft

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 19, 2020 , ... “How can ... businesses dedicated to Salivary Bioscience for more than twenty years. Together with Douglas ... Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and ...
(Date:8/7/2020)... ... 06, 2020 , ... Alucio™, a fast-growing provider of cloud-based ... and Jessica Wong have joined the company’s leadership team as Vice President of ... heads development efforts for Alucio’s flagship product, Beacon, an innovative cloud-based content management ...
(Date:7/31/2020)... ... 30, 2020 , ... Justin Zamirowski to lead upcoming launches ... focus on Type 2 diabetes and associated comorbidities. , Justin brings over 20 ... classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, the global ... has been named one of the 100 most inspiring individuals in the life-sciences ... are selected based on how they have inspired their colleagues and affected positive ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... combine up to three different materials for use with CRM, neurostimulation, vascular, and ... three materials to meet specific design requirements, performance, and cost criteria; especially where ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech ... Regulatory Solutions, in a one hour live webinar on Thursday, August 13, ... China for drugs and medical devices. Specifically, for medical devices, the NMPA has departments ...
(Date:7/10/2020)... (PRWEB) , ... July 08, 2020 , ... ... services and products, announces a significant expansion of laboratory operations through its ... for agencies implementing testing programs. , Bode-CARES provides a turnkey ...
Breaking Biology Technology:
Cached News: