HOME >> BIOLOGY >> NEWS
Forsyth scientists gain new understanding of adult stem cell regulation

Forsyth Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages that control stem cell regulation such as the message that maintain and tells a stem cell to specialize and to become part of an organ e.g.: liver or skin.

In recent years, planarians have been recognized as a great model system to molecularly dissect conserved stem cell regulatory mechanisms in vivo. Planarians have powerful regeneration capability that makes them ideal for studying this process. The Forsyth team uses planarians and other animal models to study development and regeneration.

The Forsyth team will publish this research in the August 16 issue of Development. According to the papers lead author, Nstor J. Oviedo, a postdoctoral fellow in the Forsyth Center for Regenerative and Developmental Biology, this work, highlighting the importance of direct cell-cell transfer of small molecules between stem cells and their neighbors, provides an important roadmap for learning about regeneration. These findings suggest that similar mechanisms may be extraordinarily relevant for controlling the behavior of migratory, plastic cells. Further analysis in both planarians and in vertebrates will provide crucial opportunities for understanding what drives stem cell behavior and may help medical science identify novel therapeutic targets.

The Forsyth team previously found that communication through gap-junctions (microscopic tunnels directly linking neighboring cells) controls the left-right asymmetric positioning of the internal organs during embryonic development. In this study, they turned to the role of gap junctional signals as regulators of adult stem cells in repair of injury.

Drs. Oviedo and Levin focused
'"/>

Contact: Jennifer Kelly
jkelly@forsyth.org
617-892-8602
Forsyth Institute
1-Aug-2007


Page: 1 2

Related biology news :

1. Forsyth scientists discover early key to regeneration
2. Forsyth scientists find linkages between serotonin reuptake inhibitors and bone mass
3. Forsyth scientists develop system for automated analysis of behavior
4. Forsyth issues imperative for a vaccine against cavities
5. Forsyth scientists gain greater understanding of how embryos differentiate left from right
6. New understanding of regeneration gained by Forsyth scientists
7. Forsyth scientists identify a gene responsible for facial diversity
8. Forsyth scientists find three bacteria associated with oral cancer
9. Brain chemical serotonin involved in early embryo patterning, Forsyth scientists find
10. Forsyth scientists find blue light fights gum disease culprits
11. UK scientists working to help cut ID theft

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... ... in the global health and medical technology market, announced that it has selected ... / Robotics Solution” award in the 2019 MedTech Breakthrough Awards program. , ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, ... financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... platform that provides services to more than one dozen hospitals and surgery centers ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... the appointment of Susan Murphy as the new President of Molecular Devices, replacing ... Molecular Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in a ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc ... application to the FDA for use of a person’s own adipose-derived stem cells to ... osteoarthritis in the knee. This IND is the first of several planned clinical ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for ... will educate viewers about how its technology facilitates laboratories to improve efficiency and ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative Medicine company, ... , has announced that their GMP facility for cell production is now approved ... This is an important milestone for VetStem as it expands into contract ...
(Date:5/31/2019)... (PRWEB) , ... May 29, 2019 , ... For many ... the toughest forms of cancer demand breakthrough therapies. Advances in immuno-oncology have led to ... patient’s own T cells with engineered T cell receptors known as “CARs”. The CAR ...
Breaking Biology Technology:
Cached News: