HOME >> BIOLOGY >> NEWS
Found: Key 'go-between' in heart disease

Medical researchers at the University of New South Wales (UNSW) have shed light on a little-known mechanism involved in the thickening of arteries, a process associated with heart disease.

"Essentially we've uncovered a complex network of how one bad guy regulates another bad guy," said Professor Levon Khachigian, of the Centre for Vascular Research (CVR) at UNSW. "We've also found a key to stopping this Mafioso network."

Arteries thicken when tiny molecules are increased in blood vessels. These are known as 'growth factors', which make the space in the arteries narrower and make it harder for blood to pass through.

The team's research focuses on one of four parts that make up a certain growth factor family known as PDGF. The work relates to the D chain of that growth factor.

"Our investigations have found that a key peptide hormone called angiotensin controls the expression of an important part of PDGF," said Professor Khachigian.

"Angiotensin has long been implicated in cardiovascular ailments like high blood pressure, restenosis and atherosclerosis", he said. "Angiotensin uses a couple of 'middle men' in the cell to jack up levels of PDGF D chain".

"These 'go betweens' are crucial to angiotensin's mode of action," he said. "If we take out these middle men (actually called transcription factors) we can greatly limit production of the growth factor, which is the result we would hope to see clinically."

"Our findings will provide future opportunities to tease out more specific inhibitors of growth factor production in order to reduce the incidence of common vascular disorders."

This is the first time PDGF D control has been studied at this molecular level.

The paper Inducible Platelet-Derived Growth Factor D-chain Expression by Angiotensin II and Hydrogen Peroxide Involves Transcriptional Regulation by Ets-1 and Sp1, has just been published in the influential international journal Blood.
'"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
14-Mar-2006


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. High blood pressure, low energy -- a recipe for heart failure
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. Cardio exercise benefits in male vs. female hearts
5. Using stem cells to help heart attack victims
6. System to analyze beating heart stem cells could lead to heart attack treatments
7. Cardiac patches stimulate regeneration, improve function after heart attack
8. Specific type of cell death may accelerate decompensated heart failure
9. Faulty cell membrane repair causes heart disease
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic defect links respiratory disease and congenital heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... Denver, CO (PRWEB) , ... April 29, 2016 ... ... on addressing the necessary fundamentals to transform technology into a viable company, CereScan’s ... enable growth. Mr. Kelley, a recognized leader and mentor in the Denver ...
(Date:4/29/2016)... ... ... Intelligent Implant Systems announced today that the two-level components for the Revolution™ Spinal System ... These components expand the capabilities of the system and allow Revolution™ to be utilized ... the company has seen significant sales growth in 1Q 2016, and the system is ...
(Date:4/28/2016)... 2016 The report "Cryocooler Market ... Service (Technical Support, Product Repairs & Refurbishment, Preventive Maintenance, ... to 2022", published by MarketsandMarkets, the global market is ... at a CAGR of 7.29% between 2016 and 2022. ... 94 Figures spread through 159 Pages and in-depth TOC ...
(Date:4/28/2016)... ... April 28, 2016 , ... Connecticut Innovations ... growing companies, today announced the launch of VentureClash , a $5 million ... , “VentureClash looks to attract the best early-stage companies here in Connecticut, ...
Breaking Biology Technology:
Cached News: