HOME >> BIOLOGY >> NEWS
Found: Key 'go-between' in heart disease

Medical researchers at the University of New South Wales (UNSW) have shed light on a little-known mechanism involved in the thickening of arteries, a process associated with heart disease.

"Essentially we've uncovered a complex network of how one bad guy regulates another bad guy," said Professor Levon Khachigian, of the Centre for Vascular Research (CVR) at UNSW. "We've also found a key to stopping this Mafioso network."

Arteries thicken when tiny molecules are increased in blood vessels. These are known as 'growth factors', which make the space in the arteries narrower and make it harder for blood to pass through.

The team's research focuses on one of four parts that make up a certain growth factor family known as PDGF. The work relates to the D chain of that growth factor.

"Our investigations have found that a key peptide hormone called angiotensin controls the expression of an important part of PDGF," said Professor Khachigian.

"Angiotensin has long been implicated in cardiovascular ailments like high blood pressure, restenosis and atherosclerosis", he said. "Angiotensin uses a couple of 'middle men' in the cell to jack up levels of PDGF D chain".

"These 'go betweens' are crucial to angiotensin's mode of action," he said. "If we take out these middle men (actually called transcription factors) we can greatly limit production of the growth factor, which is the result we would hope to see clinically."

"Our findings will provide future opportunities to tease out more specific inhibitors of growth factor production in order to reduce the incidence of common vascular disorders."

This is the first time PDGF D control has been studied at this molecular level.

The paper Inducible Platelet-Derived Growth Factor D-chain Expression by Angiotensin II and Hydrogen Peroxide Involves Transcriptional Regulation by Ets-1 and Sp1, has just been published in the influential international journal Blood.
'"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
14-Mar-2006


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. High blood pressure, low energy -- a recipe for heart failure
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. Cardio exercise benefits in male vs. female hearts
5. Using stem cells to help heart attack victims
6. System to analyze beating heart stem cells could lead to heart attack treatments
7. Cardiac patches stimulate regeneration, improve function after heart attack
8. Specific type of cell death may accelerate decompensated heart failure
9. Faulty cell membrane repair causes heart disease
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic defect links respiratory disease and congenital heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... Durham, NC (PRWEB) , ... June 23, 2016 , ... ... Odense University Hospital in Denmark detail how a patient who developed lymphedema after being ... (fat) tissue. The results could change the paradigm for dealing with this debilitating, frequent ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
Breaking Biology Technology:
Cached News: