HOME >> BIOLOGY >> NEWS
Found: Key 'go-between' in heart disease

Medical researchers at the University of New South Wales (UNSW) have shed light on a little-known mechanism involved in the thickening of arteries, a process associated with heart disease.

"Essentially we've uncovered a complex network of how one bad guy regulates another bad guy," said Professor Levon Khachigian, of the Centre for Vascular Research (CVR) at UNSW. "We've also found a key to stopping this Mafioso network."

Arteries thicken when tiny molecules are increased in blood vessels. These are known as 'growth factors', which make the space in the arteries narrower and make it harder for blood to pass through.

The team's research focuses on one of four parts that make up a certain growth factor family known as PDGF. The work relates to the D chain of that growth factor.

"Our investigations have found that a key peptide hormone called angiotensin controls the expression of an important part of PDGF," said Professor Khachigian.

"Angiotensin has long been implicated in cardiovascular ailments like high blood pressure, restenosis and atherosclerosis", he said. "Angiotensin uses a couple of 'middle men' in the cell to jack up levels of PDGF D chain".

"These 'go betweens' are crucial to angiotensin's mode of action," he said. "If we take out these middle men (actually called transcription factors) we can greatly limit production of the growth factor, which is the result we would hope to see clinically."

"Our findings will provide future opportunities to tease out more specific inhibitors of growth factor production in order to reduce the incidence of common vascular disorders."

This is the first time PDGF D control has been studied at this molecular level.

The paper Inducible Platelet-Derived Growth Factor D-chain Expression by Angiotensin II and Hydrogen Peroxide Involves Transcriptional Regulation by Ets-1 and Sp1, has just been published in the influential international journal Blood.
'"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
14-Mar-2006


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. High blood pressure, low energy -- a recipe for heart failure
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. Cardio exercise benefits in male vs. female hearts
5. Using stem cells to help heart attack victims
6. System to analyze beating heart stem cells could lead to heart attack treatments
7. Cardiac patches stimulate regeneration, improve function after heart attack
8. Specific type of cell death may accelerate decompensated heart failure
9. Faulty cell membrane repair causes heart disease
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic defect links respiratory disease and congenital heart disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Found Key between heart disease

(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
(Date:6/29/2015)... , June 24, 2015 ... of the "Latin America Biomedical Sensors Market - ... offering. The Latin America Biomedical Sensors market ... CAGR of 2.04% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:6/25/2015)... LAKE CITY , June 25, 2015  Imagine ... first steps toward a healthier, happier life. That,s exactly ... is designed to do. The cutting-edge, portable health program ... offers real-life solutions to help improve your lifestyle and ... Association awards dinner and gala Wednesday night, USANA,s THA ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Latin America Biomedical Sensors Market Report 2015-2020 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2
(Date:7/28/2015)... ... July 28, 2015 , ... In terms of value, aluminium ... production volume reached close to 1.84 million tonnes in the same year. As ... of the region’s total aluminium hydroxide production; the country’s aluminium hydroxide production posted ...
(Date:7/28/2015)... , July 21, 2015 Research and ... of the "Biomedical Refrigerators and Freezers Market ... and Forecast 2014 - 2022" report to ... refrigerators and freezers market has been segmented based ... blood banks, and others. The others segment includes ...
(Date:7/28/2015)... July 28, 2015 Deerfield Management Company, L.P. ... Fund, L.P., which will invest in groundbreaking advancements in ... diseases, cancer, and orphan diseases. The venture capital fund ... therapeutics are developed and improve the way healthcare is ... the largest healthcare-focused venture funds in the sector, will ...
(Date:7/28/2015)... , July 28, 2015  Kerastem Technologies announce that ... the U.S. FDA Center For Biologics Evaluation and Research ... conduct a clinical trial investigating the safety and feasibility ... and early male pattern baldness (androgenic alopecia). ... follows initial clinical work in Europe ...
Breaking Biology Technology:EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2
Cached News: