HOME >> BIOLOGY >> NEWS
Found: Key 'go-between' in heart disease

Medical researchers at the University of New South Wales (UNSW) have shed light on a little-known mechanism involved in the thickening of arteries, a process associated with heart disease.

"Essentially we've uncovered a complex network of how one bad guy regulates another bad guy," said Professor Levon Khachigian, of the Centre for Vascular Research (CVR) at UNSW. "We've also found a key to stopping this Mafioso network."

Arteries thicken when tiny molecules are increased in blood vessels. These are known as 'growth factors', which make the space in the arteries narrower and make it harder for blood to pass through.

The team's research focuses on one of four parts that make up a certain growth factor family known as PDGF. The work relates to the D chain of that growth factor.

"Our investigations have found that a key peptide hormone called angiotensin controls the expression of an important part of PDGF," said Professor Khachigian.

"Angiotensin has long been implicated in cardiovascular ailments like high blood pressure, restenosis and atherosclerosis", he said. "Angiotensin uses a couple of 'middle men' in the cell to jack up levels of PDGF D chain".

"These 'go betweens' are crucial to angiotensin's mode of action," he said. "If we take out these middle men (actually called transcription factors) we can greatly limit production of the growth factor, which is the result we would hope to see clinically."

"Our findings will provide future opportunities to tease out more specific inhibitors of growth factor production in order to reduce the incidence of common vascular disorders."

This is the first time PDGF D control has been studied at this molecular level.

The paper Inducible Platelet-Derived Growth Factor D-chain Expression by Angiotensin II and Hydrogen Peroxide Involves Transcriptional Regulation by Ets-1 and Sp1, has just been published in the influential international journal Blood.
'"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
14-Mar-2006


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. High blood pressure, low energy -- a recipe for heart failure
3. Abnormal fat metabolism underlies heart problems in diabetic patients
4. Cardio exercise benefits in male vs. female hearts
5. Using stem cells to help heart attack victims
6. System to analyze beating heart stem cells could lead to heart attack treatments
7. Cardiac patches stimulate regeneration, improve function after heart attack
8. Specific type of cell death may accelerate decompensated heart failure
9. Faulty cell membrane repair causes heart disease
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic defect links respiratory disease and congenital heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2017)... , Feb 10, 2017 Research ... report "Personalized Medicine - Scientific and Commercial Aspects" ... ... medicine. Diagnosis is integrated with therapy for selection of treatment ... early detection and prevention of disease in modern medicine. Biochip/microarray ...
(Date:2/8/2017)... Feb. 7, 2017  Aware, Inc. (NASDAQ: AWRE ... reported financial results for its quarter and year ended December ... of 2016 was $3.9 million compared to $6.9 million in ... quarter of 2016 was $0.6 million compared to $2.6 million ... fourth quarter of 2016 was $0.5 million, or $0.02 per ...
(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... billion by 2021 from $8.3 billion in 2016 at ... 2016 to 2021. Report Includes - An overview ... global market trends, with data from 2015 and 2016, ... 2021. - Segmentation of the market on the basis ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... -- Symic Bio, a biopharmaceutical company focused on matrix ... announced today the completion of enrollment for the SHIELD ... trial will evaluate the safety and efficacy of SB-030, ... restenosis following angioplasty. "We,re pleased to ... Nathan Bachtell , M.D., Chief Medical Officer of ...
(Date:2/24/2017)... ... , ... FireflySci, Inc is an explosive small business that continues to grow ... bringing their powerful cuvette and spectrophotometer calibration to the spectroscopy world. ... on as they add yet another mark on the global map. , With distributors ...
(Date:2/24/2017)... 2017  OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS), a ... Key Opinion Leader event to highlight new clinical data ... presentation at the upcoming 2017 ASCO-SITC Immuno-Oncology Symposium and ... be held in-person and via live webcast on Tuesday, ... PST at the Lotte New York Palace Hotel in ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... portfolio to include an array of biochemical analyses critical for Lead Discovery. ... drive their hit-to-lead and SAR programs, including inhibitor potency and selectivity, mechanism of ...
Breaking Biology Technology:
Cached News: