Adams' work suggests the possibility that this cancer arises because PML is unable to do its job in forming SAHF. If so, then extrapolating from recent findings in other cancers, inactivation of PML, HIRA, ASF1a and formation of SAHF may also contribute to other human cancers.
Future work in Adams' lab will define the molecular details by which HIRA, ASF1a and PML make SAHF. Ultimately, this work might allow rationale design of therapeutics to treat cancer patients and even alleviate some aspects of human aging.
Adams' co-authors on the new paper include postdoctoral associates Rugang Zhang, Ph.D., and Xiaofen Ye, Ph.D., graduate student Maxim V. Poustovoitov of Russian State Medical University in Moscow, scientific technicians Hidelita A. Santos and Wei Chen, staff scientist Ilya G. Serebriiskii, Ph.D., structural and computational biologist Roland L. Dunbrack, Ph.D., and staff scientist Adrian A. Canutescu, M.D., all at Fox Chase; Sally M. Daganzo, Ph.D., Jan P. Erzberger, Ph.D., James M. Berger, Ph.D., and Paul D. Kaufman, Ph.D., of Lawrence Berkeley National Laboratory; and John R. Pehrson, Ph.D., of the University of Pennsylvania School of Veterinary Medicine.
Poustovoitov is working in Adams' laboratory as part of a novel partnership with the Russian medical and scientific institutions to provide training at Fox Chase for master's- and doctoral-level students. Begun in 1998 with Russian State Medical University, the partnership has expanded over the years to include more students and more affiliations with premier Russian research institutions. Students typically intern at Fox Chase for about 18 months, althou
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Contact: Karen C. Mallet
karen.mallet@fccc.edu
215-728-2700
Fox Chase Cancer Center
3-Jan-2005