HOME >> BIOLOGY >> NEWS
Fox Foundation grant funds major gene therapy advance for treatment of Parkinson's disease

An innovative gene therapy approach pioneered by Pennsylvania-based RheoGene Inc. will be further refined and tested in preliminary clinical trials within four years, thanks to a $4.2 million grant from the Michael J. Fox Foundation for Parkinson's Research (MJFF).

A wholly owned affiliate of the University of Pittsburgh Medical Center (UPMC), RheoGene Inc. has developed technology to manage gene expression, a key component of gene-based therapies. RheoGene's therapeutic system uses a patented small-molecule mediator that can turn genes "on" or "off" as well as adjust the level of gene activity similar to the way a rheostat regulates electric current.

"This project has the potential to revolutionize the clinical application of gene therapy not only for the millions of people with Parkinson's disease, but for countless numbers afflicted by other health ailments as well," said Deborah W. Brooks, MJFF president and CEO. "It is a natural fit with the foundation's commitment to drive innovative technology that will have a significant impact on patients' lives."

Parkinson's disease gradually destroys brain cells that produce dopamine, a chemical messenger crucial for the cellular communication that controls muscle movement. As dopamine levels drop, symptoms increase. These include tremors in the arms, legs and face; periodically stiff or frozen limbs; slow movement; and impaired balance and coordination. In the United States, at least 500,000 and perhaps as many as 1.5 million people are thought to have Parkinson's disease, with 50,000 new cases being diagnosed each year, according to the National Institute of Neurological Disorders and Stroke, a division of the National Institutes of Health. Because risk increases with age, these rates will increase as the population ages.

Current treatment options focus on replacing lost dopamine with the drug levodopa (L-dopa), which converts to dopamine in the brain, or brain surgery to control tremo
'"/>


5-Jan-2006


Page: 1 2 3

Related biology news :

1. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
2. European Science Foundations Forward Look reaches out beyond the endless frontiers
3. Elsevier partners with National Natural Science Foundation of China
4. NY Stem Cell Foundations 2nd Annual Translational Stem Cell Research Conference
5. ACMG Foundation announces 2007-2008 Luminex/ACMGF award recipient
6. The BBVA Foundation commits 2.4 million euros to research in Ecology and Conservation Biology
7. Computer science professor awarded $400,000 from National Science Foundation
8. UTSA neurobiologist awarded $225,000 from Whitehall Foundation
9. Juvenile Diabetes Research Foundation salutes passage of Senate stem cell bill
10. Pezcoller Foundation-AACR International Award for Cancer Research recognizes Mina J. Bissell
11. Grant to Yale from Simons Foundation to explore genetic causes of autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... May 21, 2019 , ... Experiential tourism, a trend encompassing culinary ... the last several years. And according to a recent report by Skift, a ... In fact, more and more travelers are wanting their journeys to be authentic and ...
(Date:5/21/2019)... ... ... The ASGCT Clinical Trials Finder is a customizable search engine for ... curated daily from ClinicalTrials.gov ensures the most up-to-date and applicable listings anywhere in the ... the development of the ASGCT Clinical Trials Finder reviewed the relevance of ...
(Date:5/16/2019)... ... May 16, 2019 , ... SFC Fluidics, Inc. (SFC) has partnered ... and Discovery Partnership that was awarded to SFC Fluidics in 2018 by JDRF. , ... pancreas (AP) system for people with type 1 diabetes (T1D). By accelerating the development ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , May ...
(Date:4/18/2019)... Mass. (PRWEB) , ... April 18, 2019 , ... ... fossil fuels, a research team that includes a chemical engineer at Worcester Polytechnic ... exotic microorganism that may make it possible to manufacture isobutanol and other biofuels ...
(Date:4/10/2019)... , ... April 10, 2019 ... ... regenerative medicine manufacturing technology leaders, have locked into multiple agreements to help ... Companies across the regenerative medicine industry, ranging from synthetic biology companies that ...
Breaking Biology Technology:
Cached News: