HOME >> BIOLOGY >> NEWS
Fragment of yellow fever virus may hold key to safer vaccine

In one of the first molecular studies of the human antibody response to yellow fever, Howard Hughes Medical Institute (HHMI) researchers and their colleagues have found the crucial bit of virus that people's immune systems need to spot and quash this often-fatal re-emerging disease.

The findings may help scientists improve the existing vaccine, which has rare but severe side effects, said Jan ter Meulen, an HHMI international research scholar and associate professor of virology at Leiden University Medical Center in The Netherlands.

The group has identified a specific region on one of the viral proteins that elicits an immune response. Antibodies produced by the immune system interact with this part of the protein, known as a neutralizing epitope, to fight off infection. To protect people from the disease, yellow fever vaccines must contain this essential fragment of instruction to the immune system, said ter Meulen, senior author of a study published in the July 5, 2005, issue of the journal Virology and published early online.

These days, the horror of Ebola or Marburg hemorrhagic fever grabs more attention, but yellow fever is the original viral hemorrhagic fever. It strikes more than 200,000 people a year, mostly in Africa, killing about 30,000 of them, the World Health Organization estimates. No drug treatment is effective against the virus.

Since yellow fever is spread by mosquitoes, much of America has been safe from the disease thanks to control efforts aimed at the insects and a highly effective vaccine that has been available for 60 years. Vaccination is the key strategy for people living in and traveling to tropical Africa, South America, and several Caribbean Islands, where yellow fever is endemic.

In the last 20 years, however, yellow fever has been on the rise, mostly due to the lapse of immunization programs in high risk areas. More recently, serious and potentially fatal side effects from the vaccine have
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
16-Jun-2005


Page: 1 2 3

Related biology news :

1. Smithsonian Fragmentation Project threatened by Amazon Colonization Plan
2. Fragmentation rapidly erodes Amazonian biodiversity
3. Fragmented habitats no ultimate refuges for forest-dwelling tropical birds
4. Genome of yellow fever/dengue fever mosquito sequenced
5. Discovery of the first resistance gene to rice yellow mottle virus
6. Red is for hummingbirds, yellow for moths
7. Turning green into yellow
8. New bacterium discovered -- related to cause of trench fever
9. New genes identified in childhood fever-related seizures
10. Discovery could lead to better control of hemorrhagic fever viruses
11. Dengue and other hemorrhagic fevers: Towards a first potential treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2019)... ... June 24, 2019 , ... According to the World ... the four most common STDs: chlamydia, gonorrhea, trichomoniasis (or "trich") and syphilis. And that’s ... and bisexual African American men accounted for the largest number of HIV diagnoses (9,807), ...
(Date:6/18/2019)... ... June 18, 2019 , ... Cirrascale Cloud Services ®, ... Workstations-as-a-Service as part of its dedicated, multi-GPU, deep learning cloud offerings. Powered by ... feature NVIDIA® Quadro RTX™ GPUs for up to 260 teraflops of compute performance ...
(Date:6/14/2019)... ... ... Molecular diagnostics segment is the fastest-growing segment within the global IVD market. The ... are expected to drive the growth are infectious diseases, cancer, and transplant diagnostics. ... The World Molecular Diagnostics Market, 8th Edition . , The discovery of the structure ...
Breaking Biology News(10 mins):
(Date:5/21/2019)... Ethiopia (PRWEB) , ... May 21, 2019 , ... ... Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated ... and malting industry in Africa. The event, which is supported through a partnership ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the magic ... beverage products rely on these ingredients to create stable quality food that can ... paradigm shift triggers food formulators to seek out alternatives for starches, gums and ...
(Date:5/14/2019)... Calif. (PRWEB) , ... May 14, 2019 , ... ... office expansion, effectively doubling its space from 2,500 to 5,000 square feet. , ... Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home ...
(Date:5/7/2019)... (PRWEB) , ... May 06, 2019 , ... ... go-to resource for the growing number of repositories being asked to store cellular ... grateful to the team of contributors who are world leaders, who have shared ...
Breaking Biology Technology:
Cached News: