HOME >> BIOLOGY >> NEWS
Free-energy theory borne out in large-scale protein folding

HOUSTON, Oct. 3, 2005 -- In unprecedented new research, scientists at Rice University have combined theory and experiment for the first time to both predict theoretically and verify experimentally the protein-folding dynamics of a large, complex protein.

The interdisciplinary research appears this week in two back-to-back papers in the Proceedings of the National Academy of Sciences.

"Researchers have successfully combined computer modeling and experimental results in folding studies for small proteins, but this is the first effective combination for a large, multi-domain protein," said study co-author Kathleen Matthews, Dean of the Wiess School of Natural Sciences and Stewart Memorial Professor of Biochemistry. "Pioneering efforts were required to establish comparable experimental and theoretical data, and the method worked remarkably well. We expect others to adopt it in their own studies."

Proteins are the workhorses of biology. At any given time, each cell in our bodies contains 10,000 or more of them. Each of these proteins is a chain of amino acids strung end-to-end like beads in necklace. For longer proteins, the chain can contain hundreds of amino acids.

Thanks to modern genomics, scientists can use DNA to decipher the amino acid sequence in a protein. But knowing the sequence gives no clue to the protein's function, because function is inextricably tied to shape, and every protein self-assembles into its characteristic shape within seconds of being created.

"The folded, functional form of the protein is what really matters, and our interest is in creating a folding roadmap of sorts, a plot of the thermodynamic route that the protein follows as it moves toward equilibrium," said co-author Cecilia Clementi, the Norman Hackerman-Welch Young Investigator Assistant Professor of Chemistry.

The Rice research team included Clementi, Clementi's graduate student Payel Das, experimentalist Pernilla Wittung-Stafshede, ass
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
3-Oct-2005


Page: 1 2 3

Related biology news :

1. Autism theory put to the test with new technology
2. Support for chromosomal theory of cancer found in cancers development of drug resistance
3. New genetic data overturn long-held theory of limb development
4. Oregon researchers involved in new Clovis-age impact theory
5. Water theory is watertight, researchers say
6. Hofmeyr skull supports the Out of Africa theory
7. Speak, memory: Research challenges theory of memory storage
8. Varied diet of early hominid casts doubt on extinction theory, says Colorado U study
9. Computing catches up with theory
10. Genetic research at Childrens Hospital of Pittsburgh reinforces theory of evolution
11. Scientists develop first comprehensive theory explaining Madagascars rich biodiversity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2019)... ... March 13, 2019 , ... Leak Detection Associates , the leading global ... Industries, is excited to announce that it will be returning to INTERPHEX ... newly installed and highly experienced management team immediately marked Interphex as the show ...
(Date:3/9/2019)... Calif. (PRWEB) , ... March 07, 2019 , ... ... of a full day workshop presented by University of California Riverside’s EPIC ... held from 8 a.m. to 6 p.m. on Tuesday, March 17, 2019. The location ...
(Date:3/9/2019)... ... March 08, 2019 , ... Ace Laboratories, ... Well-Mints™ resveratrol + ribose hard candy lozenges ( http://www.well-mints.com ). , Well-Mints™ each ... flavored hard candy base dusted with powdered sugar. , Well-Mints'™ patented technology delivers ...
Breaking Biology News(10 mins):
(Date:3/12/2019)... (PRWEB) , ... March 11, 2019 , ... ... first hospital system in Colorado, and among the first in the nation, to ... around lab draws, IV placement and overall degree to which staff showed compassion ...
(Date:3/11/2019)... ... ... In this live webinar, the featured speakers will focus on the many attributes that ... how to use the information they have from the protocol and clinical trial knowledge, ... is properly designed and set up to ensure flawless execution. As clinical trial success ...
(Date:3/9/2019)... SAN DIEGO (PRWEB) , ... March 07, 2019 ... ... Agilent Technologies, is a pioneer in the development and commercialization of high performance, ... and PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and ...
(Date:3/5/2019)... ... March 05, 2019 , ... San Fransisko, or Sisko ... purchased him at four years old to pursue a career in dressage. According ... the most talented horse that she’d ever worked with. Unfortunately, Sisko suffered an ...
Breaking Biology Technology:
Cached News: