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'Friend' protein keeps nerve signals in check

petent to fuse at synapses, thereby regulating the amount of neurotransmitter released.

"If you remove tomosyn, you get exuberant neurotransmitter release," said Richmond. "This suggests tomosyn is a negative regulator of release. In other words, it dampens down the system, regulating the efficiency and strength of the synapse."

Because the nematode C. elegans uses proteins in its nervous system comparable to those in humans, Richmond suspects that forthcoming experiments involving tomosyn in mammals such as laboratory mice will show similar results.


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Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
24-Jul-2006


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