HOME >> BIOLOGY >> NEWS
Fruit fly study identifies gene mutation that regulates sensitivity to alcohol

e who are less sensitive to alcohol's impact are at greater risk for becoming alcohol dependent," he said.

The researchers exposed fruit flies to vaporized alcohol and monitored their behavior and motion patterns with sensitive tracking instruments. They isolated the flies that were less sensitive to alcohol's sedative effects. By breeding subsequent populations of mutant flies, the scientists identified the particular genetic mutation.

The researchers further showed that the white rabbit mutation disrupted the function of the RhoGAP18B gene. They also isolated a number of gene variants of RhoGAP18B, each of which had a distinctly different effect on the response to alcohol. Manipulating these genetic variants, the researchers generated flies with greater and lesser sensitivity to alcohol's sedative and stimulant effects.

The research team also detailed how signaling proteins encoded by the RhoGAP18B gene variants played an important role in reorganizing components of the adult fruit fly's central nervous system, which in turn affected the flies' behavior. Dr. Rothenfluh said the research team concluded that the RhoGAP18B gene is intimately involved in regulating behavioral responses to alcohol exposure.

The findings have implications for researchers seeking corresponding genes and molecular pathways in other animal models and humans. Antonio Noronha, Ph.D., director of NIAAA's Division of Neuroscience and Behavior, said, "If we can characterize similar genetic differences and neurobehavioral responses that underlie acute tolerance in humans, that could potentially provide new targets for the development of drugs to treat alcohol dependence."


'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
5-Oct-2006


Page: 1 2

Related biology news :

1. Fruit fly gene from out of nowhere is discovered
2. Fruit fly research may clean up conventional impressions of biology
3. Fruit bats are not blind as a bat
4. Survival of the rarest: Fruit flies shed light on the evolution of behavior
5. Fruit fly gene research may shed light on human disease processes
6. Fruit flies may pave way to new treatments for age-related heart disease
7. Fruit flies and global warming -- some like it hot
8. Fruit fly dating game provides clues to our reproductive prowess
9. Fruit juice intake among preschool children not associated with weight
10. Fruit fly aggression studies have relevance to humans, animals
11. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine

Post Your Comments:
(Date:10/22/2014)... -- Leading identity analyst firm Acuity Market Intelligence forecasts that ... will have a chip-based National eID card, including near-complete ... Asia , with its vast population, is ... 60% of all National eID cards issued between 2014 ... National eID Industry Report: 2014 Edition" — ...
(Date:10/18/2014)... Berlin, 19th October 2014 Psychological stress and stress-related ... for aging-related diseases, but the molecular mechanisms ... mechanisms may contribute to the development of ... treatments for these devastating diseases. This work ... Neuropsychopharmacology congress in Berlin., Now an international ...
(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Researchers find why depression and aging linked to increased disease risk 2
(Date:10/25/2014)... Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) ... the development of oral drug delivery systems, announced today ... present at FireRock Capital,s Micro-Cap Conference. ... Tuesday, October 28, 2014 ,Time: 9:15am EST ,Location: The ... , About The FireRock Conference  ...
(Date:10/25/2014)... , Oct 24, 2014 Research ... "Epigenetics Market by Product , Research Area & ... report to their offering. In this ... basis of products, research areas, and end users. The ... report are enzymes, instruments & consumables, kits, and reagents. ...
(Date:10/22/2014)... BOSTON , Oct. 22, 2014  Actavis plc ... pharmaceutical company, and Rhythm, a biopharmaceutical company, today announced ... acquire Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., which ... the treatment of diabetic gastroparesis and other GI functional ... Phase 2 trial of relamorelin for the treatment of ...
(Date:10/22/2014)... Massachusetts (PRWEB) October 22, 2014 ... announced the release of a new infographic, Understanding ... to create a beautifully designed, easy to follow informative ... transmission, areas of outbreak, symptoms and prevention. , "As ... discovered that the 2014 Ebola outbreak represents not only ...
Breaking Biology Technology:Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2
Cached News: