HOME >> BIOLOGY >> NEWS
Fruit fly study identifies gene mutation that regulates sensitivity to alcohol

e who are less sensitive to alcohol's impact are at greater risk for becoming alcohol dependent," he said.

The researchers exposed fruit flies to vaporized alcohol and monitored their behavior and motion patterns with sensitive tracking instruments. They isolated the flies that were less sensitive to alcohol's sedative effects. By breeding subsequent populations of mutant flies, the scientists identified the particular genetic mutation.

The researchers further showed that the white rabbit mutation disrupted the function of the RhoGAP18B gene. They also isolated a number of gene variants of RhoGAP18B, each of which had a distinctly different effect on the response to alcohol. Manipulating these genetic variants, the researchers generated flies with greater and lesser sensitivity to alcohol's sedative and stimulant effects.

The research team also detailed how signaling proteins encoded by the RhoGAP18B gene variants played an important role in reorganizing components of the adult fruit fly's central nervous system, which in turn affected the flies' behavior. Dr. Rothenfluh said the research team concluded that the RhoGAP18B gene is intimately involved in regulating behavioral responses to alcohol exposure.

The findings have implications for researchers seeking corresponding genes and molecular pathways in other animal models and humans. Antonio Noronha, Ph.D., director of NIAAA's Division of Neuroscience and Behavior, said, "If we can characterize similar genetic differences and neurobehavioral responses that underlie acute tolerance in humans, that could potentially provide new targets for the development of drugs to treat alcohol dependence."


'"/>

Contact: Gregory Roa
greg.roa@nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
5-Oct-2006


Page: 1 2

Related biology news :

1. Fruit fly gene from out of nowhere is discovered
2. Fruit fly research may clean up conventional impressions of biology
3. Fruit bats are not blind as a bat
4. Survival of the rarest: Fruit flies shed light on the evolution of behavior
5. Fruit fly gene research may shed light on human disease processes
6. Fruit flies may pave way to new treatments for age-related heart disease
7. Fruit flies and global warming -- some like it hot
8. Fruit fly dating game provides clues to our reproductive prowess
9. Fruit juice intake among preschool children not associated with weight
10. Fruit fly aggression studies have relevance to humans, animals
11. Psst! Coffee drinkers: Fruit flies have something to tell you about caffeine

Post Your Comments:
(Date:10/29/2014)... open for the Society of Interventional Radiology,s ... is the one place where interventional radiologists, ... care professionals can come together to find ... being presented, discussed and tested. , ... image-guided medicine, SIR 2015 will feature essential ...
(Date:10/29/2014)... and industrial products are in the environment – and ... them, scientists have yet to determine whether they cause ... doing that by estimating which substances people are exposed ... the ACS journal Environmental Science & Technology . ... risks to human health of any given substance depend ...
(Date:10/29/2014)... LANSING, Mich. – As bodies decompose, their types ... the clues they provide could mean the difference ... , Michigan State University is using a more ... help Detroit death-scene investigators examine these changing populations. ... as geographical location of death, gender, race, socioeconomic ...
Breaking Biology News(10 mins):SIR 2015: Interventional radiology shapes tomorrow's medicine 2MSU partners with Detroit to investigate death scenes 2
(Date:10/31/2014)... Brady (NYSE:BRC), a global leader in ... new video testimonial on the effectiveness of its ... technician at the BloodCenter of Wisconsin discusses the challenges ... hundreds of thousands of samples, and how the durability ... Brady, we design our label materials with the harsh ...
(Date:10/31/2014)... 31, 2014  Tavistock Development Co. (TDC), a ... celebrated the groundbreaking of the GuideWell Innovation Center ... The 92,000-square-foot, three-story facility is the first ... designed specifically for life sciences, health innovation, ... the 650-acre Lake Nona Medical City, near the ...
(Date:10/30/2014)... LONDON , October 30, 2014 ... Organovo Holdings Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... PCYC ), Synthetic Biologics Inc. (NYSE MKT: SYN), and ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,549.23, down 0.33%, the Dow Jones ...
(Date:10/30/2014)... 2014 Deep Research Report on Global ... and in-depth research report on the China Naltrexone ... including its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... macroeconomic environment & economic situation analysis. The report ...
Breaking Biology Technology:Brady Debuts New Lab Label Testimonial Video 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
Cached News: