HOME >> BIOLOGY >> NEWS
Fruit fly's beating heart helps identify human heart disease genes

In a discovery that could greatly accelerate the search for genetic causes of heart disease, a multi-disciplinary Duke University research team has found that the common fruit fly can serve as a powerful new model for testing human genes implicated in heart disease.

The finding is important, the Duke team said, because the entire genome of the fruit fly is well understood and catalogued, enabling researchers to systemically screen genes to identify potential gene mutations or variants implicated in human heart disease. The achievement also raises the possible of rapid screening in fruit flies of drugs to treat heart disease, said the researchers.

The team's bioengineers adapted an existing imaging technology to visualize in detail for the first time the beating of the heart of a fruit fly, an insect the size of a grain of rice. The fly's heart is about the size of the period at the end of this sentence.

After perfecting the new visualization technique, the researchers inserted into the fly genome a mutated gene that causes dilated cardiomyopathy in humans. This condition is often the cause of heart failure in humans and is characterized by heart muscle that has greatly enlarged and therefore is unable to pump blood efficiently. The moving images revealed that fly heart looked and acted just like a human heart with the same condition.

"The difficulty in performing studies to find specific genes that cause disease in humans is that you need large families with members afflicted with the disease," said Matthew J. Wolf, M.D., Ph.D., Duke Medical Center cardiology fellow and first author of paper appearing Jan. 23, 2006, in the Early Edition of the Proceedings of the National Academy of Sciences. "This can be a quite a complex and laborious undertaking. Even in mouse models of human disease, the process of screening for genes can take a long time.

"However, fruit flies, with their well-documented genome and rapid life-cycle, have t
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
23-Jan-2006


Page: 1 2 3

Related biology news :

1. Fruit fly gene from out of nowhere is discovered
2. Fruit fly research may clean up conventional impressions of biology
3. Fruit bats are not blind as a bat
4. Survival of the rarest: Fruit flies shed light on the evolution of behavior
5. Fruit fly gene research may shed light on human disease processes
6. Fruit flies may pave way to new treatments for age-related heart disease
7. Fruit flies and global warming -- some like it hot
8. Fruit fly dating game provides clues to our reproductive prowess
9. Fruit juice intake among preschool children not associated with weight
10. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
11. Fruit fly aggression studies have relevance to humans, animals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... September 21, 2018 , ... VTE can ... untreated, can lead to significant morbidity and mortality. VTE affects between 300-600,000 Americans ... autopsy. Further, PE is the leading cause of preventable hospital death and maternal ...
(Date:9/12/2018)... ... September 11, 2018 , ... Tennant ... introduce the new ChemXP™ line of high performance secondary containment coatings, designed to ... to provide Tennant Coatings’ elite certified installers with the needed solutions to protect ...
(Date:9/7/2018)... ... September 06, 2018 , ... Sensors Midwest ... show Sensors Expo & Conference , announces their partnership with Fraunhofer USA ... an IoT Enabled Industrial IoT Certification Program. Taking place on October 17, 2018 ...
Breaking Biology News(10 mins):
(Date:9/13/2018)... ... September 13, 2018 , ... Asymmetrex’s director, James L. ... have gotten in medicine, if we didn’t have the means to measure the number ... His answer, “Nowhere! And that is what’s holding up progress in stem cell ...
(Date:9/12/2018)... ... 11, 2018 , ... Sterlitech Corporation, a global leader in ... from Fluid Technology Solutions (FTS H2O) to their offering of filtration products. ... triacetate (CTA) material. The highly hydrophilic nature of the CTA FO membranes favors ...
(Date:9/7/2018)... ... September 06, 2018 , ... ... September 25th-28th is a meeting of “The industry’s preeminent event on novel drug ... discovery scientists powerful tools to study these emerging targets in a quest to ...
(Date:9/7/2018)... , ... September 06, 2018 , ... Akadeum Life Sciences ... spent his career as an executive and leader of numerous biotech companies. , ... therapy and biologics company acquired by Thompson Street Capital in St. Louis, MO. ...
Breaking Biology Technology:
Cached News: