HOME >> BIOLOGY >> NEWS
G6PD deficiency is associated with significant protection against severe, life-threatening malaria

A case-control study in two populations in Mali, West Africa has shown that glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with significant protection against severe, life-threatening malaria. Researchers from the US National Institute of Allergy and Infectious Diseases and the University of Bamako, Mali, led by Thomas E. Wellems, report the findings this week in the open access journal PLoS Medicine.

G6PD deficiency is also known as favism after the Italian word for broad beans (fava) which cause a classic reaction when eaten by people with G6PD deficiency. In males, who have only one X chromosome, mutations in the gene for G6PD on the X chromosome cause G6PD deficiency. Females who have mutations on both X chromosomes will also be deficient. G6PD is an important enzyme in red blood cells (erythrocytes), the host cells for Plasmodium falciparum, the parasite that causes the most severe form of malaria. G6PD deficiency is associated with protection against malaria, notably in Africa where one form of G6PD deficiency (G6PD A-) is widespread.

In the two populations of more than 3000 children studied in rural Mali where malaria is very frequent, G6PD deficiency in male and female children was associated with protection against severe, life-threatening malaria, but no effect was found in females who had just one abnormal gene. However, there was no significant difference in the numbers of parasites in the red blood cells of the various groups of children indicating that the deficiency does not work by stopping parasites from infecting the children. G6PD deficiency instead appears to mitigate disease processes set up by the parasitized cells in the bloodstream. The protection was confirmed by a combined analysis of these data and data from a previous study. Protection was most evident against cerebral malaria, the most frequent form of life-threatening malaria in these studies.

These results reignite the debate about t
'"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
12-Mar-2007


Page: 1 2

Related biology news :

1. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
2. Vitamin D deficiency widespread during pregnancy
3. The new form of trypanosomiasis discovered in India stems from a deficiency in apolipoproteinL-1
4. Poor athletic performance linked to vitamin deficiency
5. Dartmouth study contributes to research addressing malnutrition and iron deficiency
6. Heavy drinking can hasten the progression of the simian immunodeficiency virus disease
7. Study illuminates birth defects caused by copper deficiency
8. Study finds that nutritionally enhanced rice reduces iron deficiency
9. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates
10. Gene for immune deficiency syndromes found
11. Rapid, new test develped for inherited immune deficiency

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/20/2017)... 2017 At this year,s CeBIT Chancellor Dr. ... DERMALOG. The Chancellor came to the DERMALOG stand together with the Japanese ... CeBIT partner country. At the largest German biometrics company the two government ... and iris recognition as well as DERMALOGĀ“s multi-biometrics system.   ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , ... Well Made Simple," and 23andMe , the leading ... better food choices.  Zipongo can now provide customers with ... preferences, health goals and biometrics, but also genetic markers ... choices. Zipongo,s personalized food decision support platform ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics and ... (IP) sharing and commercialization model. , The Center for Advancing Innovation helps institutions ... this effort is bringing the IP to the attention of the entrepreneurial community ...
(Date:4/19/2017)... ... 18, 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) ... monodisperse droplets of known diameters for research applications such as for calibrating droplet ... drying monodisperse droplets. , The VOAG requires forcing liquid out of an ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces Completion of ... Leverage Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , Nobilis ... clinical trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the treatment of ...
(Date:4/19/2017)... , April 19, 2017 A new report published ... Industry Forecast, 2014-2022 ," the global market was valued at $6,769 million in ... of 9.6% from 2016 to 2022. ... Allied Market Research ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
Breaking Biology Technology:
Cached News: