HOME >> BIOLOGY >> NEWS
Gallium: A new antibacterial agent?

New antibacterial strategies are needed because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradicating chronic bacterial infections. One approach to developing new antibacterial strategies, taken by researchers from the University of Washington, Seattle, is to limit the amount of iron (Fe), which is critical for bacterial growth, to which bacteria have access.

In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pradeep Singh and colleagues show that Gallium (Ga), which is chemically similar to Fe and can disrupt biological systems by substituting for Fe, inhibits the in vitro growth of Pseudomonas aeruginonsa; even multidrug resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aeruginonsa forming biofilms, the multi-cellular bacterial communities responsible for chronic bacterial infections, and killed both free-living bacteria and bacteria in biofilms. Furthermore, inhalation of Ga protected mice from both acute and chronic P. aeruginonsa lung infections. As Ga is already FDA approved for the treatment of hypercalcemia of malignancy, these data suggest that Ga might be a promising new therapeutic for the treatment of infection with P. aeruginonsa, a major cause of infection in individuals with cystic fibrosis and of infection acquired in hospital.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2007


Page: 1

Related biology news :

1. New antibacterials being developed to tackle MRSA superbug
2. ASU researchers test antibacterial effects of healing clays
3. First human trial of antibacterial contact lens
4. CBEN: Buckyball aggregates are soluble, antibacterial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... 28, 2018 , ... Johanna Dwyer, founder and Chief Executive ... excellence in the field of intellectual property, and named Daniela Sanchez as the ... Award aims to encourage and support women in their pursuit of careers in ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... tool in clinical diagnostic laboratories. However, this technology introduces many well-described challenges ... London, which leads the South London NHS Genomic Medicine Centre. The Viapath ...
(Date:8/23/2018)... ... 2018 , ... RURO, Inc., an industry-leading lab software provider, ... growing cloud-based laboratory information system. , With the success of the streamlined version ... growth throughout 2018, the RURO team has been hard at work expanding LimitLIS® ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... August 28, 2018 , ... Cognition Corporation ®, ... lineup of talks for NAVIGATE2018 . , Ryan Ward, Director of Engineering ... annual user conference. An experienced engineer and manager with Zimmer Biomet for almost 15 ...
(Date:8/29/2018)... ... August 28, 2018 , ... LabRoots , the leading provider of interactive ... to announce the launch of a new gamification feature, allowing users to earn points ... of LabRoots most popular shirts. , Throughout each month, LabRoots users will earn points ...
(Date:8/26/2018)... ... August 24, 2018 , ... ExoCoBio Inc., based in South ... dermatitis and inhibits a variety of inflammatory targets in the journal of Stem ... mice having severe atopic dermatitis were significantly improved after administration of stem cell-derived ...
(Date:8/21/2018)... , ... August 21, 2018 ... ... software company specializing in medical device compliance and commercialization, has just released ... platform. , Written and presented by Dr. Mario Kossmann, ESEP at the ...
Breaking Biology Technology:
Cached News: