HOME >> BIOLOGY >> NEWS
Gallium: A new antibacterial agent?

New antibacterial strategies are needed because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradicating chronic bacterial infections. One approach to developing new antibacterial strategies, taken by researchers from the University of Washington, Seattle, is to limit the amount of iron (Fe), which is critical for bacterial growth, to which bacteria have access.

In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pradeep Singh and colleagues show that Gallium (Ga), which is chemically similar to Fe and can disrupt biological systems by substituting for Fe, inhibits the in vitro growth of Pseudomonas aeruginonsa; even multidrug resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aeruginonsa forming biofilms, the multi-cellular bacterial communities responsible for chronic bacterial infections, and killed both free-living bacteria and bacteria in biofilms. Furthermore, inhalation of Ga protected mice from both acute and chronic P. aeruginonsa lung infections. As Ga is already FDA approved for the treatment of hypercalcemia of malignancy, these data suggest that Ga might be a promising new therapeutic for the treatment of infection with P. aeruginonsa, a major cause of infection in individuals with cystic fibrosis and of infection acquired in hospital.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2007


Page: 1

Related biology news :

1. New antibacterials being developed to tackle MRSA superbug
2. ASU researchers test antibacterial effects of healing clays
3. First human trial of antibacterial contact lens
4. CBEN: Buckyball aggregates are soluble, antibacterial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... FRANCISCO (PRWEB) , ... February 01, 2019 , ... ... ISO 15189 Accreditation for Clinical Testing Laboratories by A2LA, which establishes requirements for ... an international standard. The laboratory is already CLIA-licensed as well as College of ...
(Date:1/25/2019)... ... January 24, 2019 , ... uBiome, the leader in microbial ... at the Jackson Laboratory (JAX), to its Scientific Advisory Board. Joining the board ... to uBiome expertise in skin microbial interactions and probiotic treatments for skin and ...
(Date:1/25/2019)... , ... January 24, 2019 , ... ... those with rare diseases , As states continue to grapple with prescription drug ... methodological and disease-specific questions policy makers should address before deciding whether to contract ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... SAN DIEGO (PRWEB) , ... January 29, 2019 ... ... fully integrated Contract Development and Manufacturing Organization (CDMO) serving the global biopharmaceutical and ... series A funding of $59.1 million backed by multiple global investors lead by ...
(Date:1/30/2019)... ... January 30, 2019 , ... The Society for Laboratory ... to discuss best practices for laboratory automation and screening. This year the conference ... year’s conference, Visikol will be at booth #345 and throughout the conference will ...
(Date:1/24/2019)... ... , ... Dr. Douglas Stramel of Advanced Care Veterinary Services in ... for nearly three years. A proponent of Regenerative Medicine, Dr. Stramel has ... using V-PET™ 2016. V-PET™ is a gravity filtration-based platelet therapy kit that produces ...
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers ... the exclusive purview of physicians. That's changing as many services now exist for ... (DTC) laboratory testing market totaled $208 million in 2018, according to Kalorama Information’s ...
Breaking Biology Technology:
Cached News: