HOME >> BIOLOGY >> NEWS
Gene discovered for type 1 diabetes in children

Pediatrics researchers at The Childrens Hospital of Philadelphia and McGill University in Montreal have identified a gene variant that raises a childs risk for type 1 diabetes, formerly called juvenile diabetes. As investigators continue to pinpoint genes contributing to diabetes, they have their eyes on providing a scientific basis for designing better treatments and preventive measures for the disease.

The research adds a new gene and new knowledge to the four genes previously discovered for type 1 diabetes, in which the immune system destroys insulin-producing beta cells in the pancreas and makes patients dependent on frequent insulin injections to keep the bodys blood sugar under control. As the project continues, the study team expects to identify additional genes (perhaps as many as 15 or 20) thought to interact with each other in the disease.

The study appeared July 15 in an advance online letter in the journal Nature.

The genotyping technology we now have available has revolutionized the way we can ask and answer research questions, said the studys lead author, Hakon Hakonarson, M.D., Ph.D., the director of the Center for Applied Genomics at The Childrens Hospital of Philadelphia. Unlike the previous technology, which was quite limited and dealt largely with relatively rare gene variants, we can now detect common genetic variants that are important in large numbers of individuals, and begin to understand how multiple genes interact in complex diseases such as diabetes.

In the discovery phase of the study, the investigators examined the genomes of 1,046 children with type 1 diabetes. These DNA samples came from patients and families followed in pediatric diabetes clinics in Philadelphia and four Canadian cities. Specifically, the researchers compared the genomes of 563 patients with type 1 diabetes with those of 1,146 matched control subjects. Those results were combined with those obtained from an independent anal
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
15-Jul-2007


Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A new brake on cellular energy production discovered
3. New target for HIV/AIDS drugs and vaccine discovered
4. Surprising new species of light-harvesting bacterium discovered in Yellowstone
5. Scratch no more: Gene for itch sensation discovered
6. Fruit fly gene from out of nowhere is discovered
7. A novel molecular dictator with a conscience discovered
8. Alzheimers prevention role discovered for prions
9. Link between obesity and enlarged heart discovered by University of Arizona researchers
10. Genetic fellow traveler discovered in Alzheimers
11. New bacterium discovered -- related to cause of trench fever

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/26/2019)... , ... October 24, 2019 , ... World Cord Blood ... parents, doctors, nurses, and midwives to learn about the current and future uses of ... Cord blood is now being used to treat and cure over 80 different life-threatening ...
(Date:10/26/2019)... ... October 25, 2019 , ... The ... in La Plata, MD. Orofacial myofunctional disorders (OMDs) are abnormal movement patterns of ... speaks. This can include anything from difficulty swallowing and limited tongue movement to ...
(Date:10/22/2019)... ... October 22, 2019 , ... Greenberg Traurig, LLP’s global ... Deal Making in the Life Sciences Sector,” with German biotech strategy consulting firm, Catenion. ... at Greenberg Traurig’s Tokyo office . , Speakers from Greenberg Traurig and Catenion ...
Breaking Biology News(10 mins):
(Date:11/2/2019)... TORONTO (PRWEB) , ... October 31, 2019 , ... ... at Adaptive Biotechnologies in a live webinar on Friday, ... application in immuno-oncology. , Immunosequencing, the science of profiling T-cell receptors (TCRs) ...
(Date:10/30/2019)... ... , ... While using cold plasma to kill cancer cells isn’t an entirely ... Mines & Technology are exploring new ways to regulate cold plasma technology to ... the technique would prove to be a drug-free, minimally invasive cancer treatment that would ...
(Date:10/29/2019)... ... ... CaroGen Corporation , a biotechnology company, today announced three distinguished additions ... Wands, MD, of Brown University , Dr. Steve Projan, PhD, FAAM, formerly ... of Wayne State University, formerly a professor at Yale University School of Medicine ...
(Date:10/29/2019)... Mass. (PRWEB) , ... October 29, 2019 , ... ... spectral signature of the skin*. Using Silios CMS-C multispectral imagers , researchers ... new approach can replace identification based on retinal imaging, face recognition, fingerprints and ...
Breaking Biology Technology:
Cached News: