HOME >> BIOLOGY >> NEWS
Gene expression becomes heterogeneous with age in humans and rats

In a study of the effects of aging on gene expression, researchers have found that variation in gene expression among individuals tends to increase with age. The findings, which impact our understanding of the molecular forces that govern age-related changes, are reported in the May 23rd issue of Current Biology by Mehmet Somel and colleagues at the Max Planck Institute for Evolutionary Anthropology and the University of Cambridge.

One long-standing observation concerning the physiological decline that accompanies aging is its variability--some people age better than others. However, there has thus far been little or no evidence supporting the existence of similar heterogeneity at the level of gene expression. Lack of such evidence, in turn, gives support to a "programmed aging" hypothesis and argues against the more commonly accepted "stochastic aging" model, in which random biological events play an important role.

In the new work, researchers put to the test the question of whether gene-expression heterogeneity increases with age. Using a wide range of expression data from both humans and rats, the researchers showed that levels of gene expression become more variable with age. Furthermore, they found that the tendency toward increased variation is not restricted to a specific set of genes, implying that increased heterogeneity is the outcome of random processes such as genetic mutation.

These observations corroborate the notion that aging is underpinned by stochastic events. That said, the authors of the study point out that the observed increases in expression variation are surprisingly small, leaving plenty of room for further explanations regarding the relationship between aging-related changes at the organismal level and the underlying molecular mechanisms of aging. Nevertheless, the new results show that with the increasing amounts of molecular data available to researchers, scientists will now experience improved opportunities to
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
22-May-2006


Page: 1 2

Related biology news :

1. A low expression of MX2 gene exists in the white blood cells of narcoleptics
2. Gene expression pattern could lead to improved treatment of pediatric septic shock
3. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
4. Clocking in and out of gene expression
5. High cholesterol diets modify gene expression in atherosclerosis
6. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
7. Decoding gene expression in cancer tumors using noninvasive imaging
8. Growing nerve cells in 3-D dramatically affects gene expression
9. XDx to present recent success with AlloMap molecular expression testing
10. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
11. Clues to gene expression in cystic fibrosis will guide research

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene expression becomes heterogeneous with age humans and rats

(Date:5/25/2015)... SYDNEY , May 25, 2015  Australia,s market ... inception stage, although 2014 saw the advent of several ... on 24 April 2015 is expected to ignite interest ... devices in Australia . This in ... the industry and drive new partnerships amongst vendors and ...
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/21/2015)... The Sync Project™ , a global ... today announced a collaborative partnership with Berklee,s Institute ... on collaboration on original research, joint course development and ... collaboration, The Sync Project and BerkleeICE are exploring the ... the 2015-2016 academic year.  The course ...
Breaking Biology News(10 mins):Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 2Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 3Australian wearables market to grow at CAGR of 78%; revenue of A$1 billion by 2018, says Frost & Sullivan 4Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3
(Date:5/27/2015)... , May 26, 2015 Research ... of the "Global Breast Cancer Monoclonal Antibodies ... Globally, Roche seems to dominate the ... inventory. Its block buster molecule, Herceptin has been ... It was found that breast cancer cells become ...
(Date:5/27/2015)... /CNW/ - CQDM, Brain Canada and the Ontario ... (6) multi-disciplinary and multi-provincial research teams across Canada to ... Brain strategic initiative. To this amount, $1.5M is added ... This exciting announcement was made today at the annual ... presence of Inez Jabalpurwala, President and CEO of ...
(Date:5/27/2015)... Empowering biomedical researchers with richer, ... Inc. today announced its MR Compatible Small Animal ... Scanner uses silicon photomultiplier detector technology, so it ... from manufacturers like Bruker and Agilent,” said James ... “This enables simultaneous PET and MRI data acquisition ...
(Date:5/27/2015)... OAKLAND, Calif. , May 27, 2015  Two ... tinkerers, biotech professionals, hackers and citizen scientists, ... a $30,000 crowdfunding campaign promoting its mission to democratize ... city,s Temescal District. ... Based out ...
Breaking Biology Technology:Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10Cubresa Launches Simultaneous PET/MRI Technology 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 3
Cached News: