HOME >> BIOLOGY >> NEWS
Gene expression becomes heterogeneous with age in humans and rats

In a study of the effects of aging on gene expression, researchers have found that variation in gene expression among individuals tends to increase with age. The findings, which impact our understanding of the molecular forces that govern age-related changes, are reported in the May 23rd issue of Current Biology by Mehmet Somel and colleagues at the Max Planck Institute for Evolutionary Anthropology and the University of Cambridge.

One long-standing observation concerning the physiological decline that accompanies aging is its variability--some people age better than others. However, there has thus far been little or no evidence supporting the existence of similar heterogeneity at the level of gene expression. Lack of such evidence, in turn, gives support to a "programmed aging" hypothesis and argues against the more commonly accepted "stochastic aging" model, in which random biological events play an important role.

In the new work, researchers put to the test the question of whether gene-expression heterogeneity increases with age. Using a wide range of expression data from both humans and rats, the researchers showed that levels of gene expression become more variable with age. Furthermore, they found that the tendency toward increased variation is not restricted to a specific set of genes, implying that increased heterogeneity is the outcome of random processes such as genetic mutation.

These observations corroborate the notion that aging is underpinned by stochastic events. That said, the authors of the study point out that the observed increases in expression variation are surprisingly small, leaving plenty of room for further explanations regarding the relationship between aging-related changes at the organismal level and the underlying molecular mechanisms of aging. Nevertheless, the new results show that with the increasing amounts of molecular data available to researchers, scientists will now experience improved opportunities to
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
22-May-2006


Page: 1 2

Related biology news :

1. A low expression of MX2 gene exists in the white blood cells of narcoleptics
2. Gene expression pattern could lead to improved treatment of pediatric septic shock
3. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
4. Clocking in and out of gene expression
5. High cholesterol diets modify gene expression in atherosclerosis
6. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
7. Decoding gene expression in cancer tumors using noninvasive imaging
8. Growing nerve cells in 3-D dramatically affects gene expression
9. XDx to present recent success with AlloMap molecular expression testing
10. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
11. Clues to gene expression in cystic fibrosis will guide research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/9/2016)... 9, 2016  Crossmatch ® , a leading ... today announced the addition of smart features to ... multi-factor authentication platform. New contextual and application-specific authentication ... security where it,s needed most — while minimizing ... . --> Washington, DC ...
(Date:3/2/2016)... DUBLIN , March 2, 2016 /PRNewswire/ ... has announced the addition of the  "Global ... to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... sector to grow at a CAGR of ... http://www.researchandmarkets.com/research/wzwqtz/global_biometrics ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced today that ... 510(k) for sale in the United States. These components expand the capabilities of ... With one-level sales beginning in October of 2015, the company has seen significant sales ...
(Date:4/28/2016)... 2016 Q BioMed Inc. ... CEO  was featured in an article he wrote ... Fear To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... is an essential business journal for life science ... to Big Pharmas. Their content is designed to ...
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
Breaking Biology Technology:
Cached News: