HOME >> BIOLOGY >> NEWS
Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients

PITTSBURGH, May 30 -- Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease typically characterized by the slow but progressive onset of shortness of breath or cough. Most patients live about five years after diagnosis. However, according to a new study being published today in the online journal PLoS ONE, a subset of patients with a specific genetic profile has a much more rapid progression to complete pulmonary failure and death without a lung transplant.

Based on observations in the clinic that some IPF patients display a more rapidly progressing disease course, researchers at the Simmons Center for Interstitial Lung Disease at the University of Pittsburgh School of Medicine, collaborating with pulmonary scientists in Mexico and California, used DNA microarray analysis to measure the gene expression patterns of 26 rapid progressors and 88 slow progressors. They identified 437 differentially expressed genes between the groups. Specifically, lungs of rapid progressors, who were predominantly males who smoked, overexpressed genes involved in the development of tissues and organs (morphogenesis), oxidative stress, cell migration and proliferation and genes from fibroblasts and smooth muscle cells.

According to Naftali Kaminski, M.D., director of the Simmons Center and director of the Lung Translational Genomics Center, division of pulmonary, allergy and critical care medicine, University of Pittsburgh School of Medicine, these findings offer strong evidence that rapid progressors represent a distinct clinical phenotype compared with the usual slower progressing patients.

"We are only now starting to really understand IPF and to characterize it," Dr. Kaminski said. "Therefore, it is critical for patients with the disease to be seen in centers that are actively involved in IPF research, so we can help them better decide a course of action."

These findings also highlight the variability in the progression and outcome o
'"/>

Contact: Michele Baum
BaumMD@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
30-May-2007


Page: 1 2

Related biology news :

1. A low expression of MX2 gene exists in the white blood cells of narcoleptics
2. Gene expression pattern could lead to improved treatment of pediatric septic shock
3. Boston Univeristy bioengineers devise dimmer swith to regulate gene expression in mammal cells
4. Clocking in and out of gene expression
5. High cholesterol diets modify gene expression in atherosclerosis
6. Decoding gene expression in cancer tumors using noninvasive imaging
7. Growing nerve cells in 3-D dramatically affects gene expression
8. XDx to present recent success with AlloMap molecular expression testing
9. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
10. Clues to gene expression in cystic fibrosis will guide research
11. Protein overexpression at heart of heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... N.Y. (PRWEB) , ... August 13, 2018 , ... ... new 2017/18 products, the Staticmaster® P-2021-5502 and P-2021-5602 Cleanroom Ionizing Gun. , ... VTE-208 Filtered Nitrogen Air Gun, P-2021 ionizing cartridge, 0.5-micron filter and electropolished OSHA-compliant ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... solutions for the global scientific community, announced today the establishment of a new ... division is to foster and support scientific collaborations with ActiGraph’s academic and pharmaceutical ...
(Date:8/14/2018)... ... August 14, 2018 , ... From reconstruction of craniofacial syndrome ... better understanding of congenital heart defects, 3-D printing is providing exciting approaches to ... of Birth Defects Research (DOI: 10.1002/bdr2.1367). , The special ...
Breaking Biology News(10 mins):
(Date:7/27/2018)... ... July 27, 2018 , ... ... of the Biotechnology Innovation Organization (BIO) met with U.S. Environmental Protection Agency ... a Toxic Substances Control Act (TSCA) Inventory Representation and Equivalency Determinations for ...
(Date:7/25/2018)... ... July 25, 2018 , ... Vium, Inc. http://www.vium.com ... and Vium Cloud approach to accelerate preclinical drug discovery and development, today announced ... announced the appointment of Jeff Caron to the newly formed role of Senior ...
(Date:7/24/2018)... ... July 23, 2018 , ... ... energy treated nutraceutical to increase immunity and improve anti-inflammatory, and immune function responses. ... assessed in the preclinical research were significantly reduced. Results are as follows:, ...
(Date:7/22/2018)... ... July 19, 2018 , ... CallTower ... joined their team. With more than ten years of strategic, result-oriented Channel experience ... expertise as CallTower’s Channel Director for the Southwest and Mountain region. , As ...
Breaking Biology Technology:
Cached News: