HOME >> BIOLOGY >> NEWS
Gene identified for Crohn's disease in children

Pediatrics researchers have identified a gene variant that raises a childs risk of Crohns disease, a chronic and painful condition attributed to inflammation of the gastrointestinal tract.

The research reinforces previous results by German researchers, who found the same gene variant associated with the adult form of Crohns disease.

Researchers from The Childrens Hospital of Philadelphia and The University of Pennsylvania reported their results in a letter in the August issue of the journal Gut.

Because Crohns disease is complex, with multiple genes interacting with each other and with environmental factors, its important to sort out specific genes and to replicate previous findings, said the studys first author, Robert N. Baldassano, M.D., director of the Center for Pediatric Inflammatory Bowel Disease at Childrens Hospital. There are different types of Crohns disease, so classifying types by genetic profiles may help us select the most appropriate treatments for each patient.

The study compared the genomes of 143 children with Crohns disease to genomes of 282 matched control subjects. The study team found that 64 percent of children with Crohns disease had a specific variant form of the gene ATG16L1, compared with 52 percent of the healthy children. The odds ratio for children with the gene variant was 1.62 compared to control children, meaning that those who have the variant were 62 percent more likely to have Crohns disease than children with the more common allele.

A separate test that analyzed trios (a Crohns patient and both parents) also found an association between the ATG16L1 gene variant and disease symptoms. This finding strengthened the results of the pediatric case-control study.

The genome-wide association study, which used highly automated analytic equipment to scan each patients DNA for more than half a million genetic markers, was performed at the Center for Applied Genomics at Childr
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
18-Jul-2007


Page: 1 2 3

Related biology news :

1. Link identified between Alzheimers disease and glaucoma
2. New gene mutation identified in common type of dementia
3. Allergy molecule identified
4. Gene responsible for common hearing loss identified for first time
5. Muscle weakness: New mutation identified
6. Tumor vessels identified by unique molecular markers
7. Extra-aggressive form of idiopathic pulmonary fibrosis identified
8. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
9. Pediatric cancer stem cell identified: understanding the origin of ERMS
10. New host species for avian influenza identified
11. Master regulatory gene of epithelial stem cells identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... August 15, 2019 , ... ... what? As serialization mandates become increasingly complex, and aggregation becomes fully applied in ... software is the best long-term solution. , Until now, most regulations?including the Drug ...
(Date:8/14/2019)... , ... August 14, 2019 , ... ... 4Q/2019, will explore how developments in microbiome therapeutics are helping to promote normal ... for more information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, which ...
(Date:8/14/2019)... TORONTO (PRWEB) , ... August 14, 2019 , ... Join ... live session on Tuesday, September 10, 2019 at 1pm EDT to learn ... stratification and effective management. , NAFLD is the most common diffuse liver disease, ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... AUBURN, Mass. (PRWEB) , ... July 18, 2019 ... ... PI (Physik Instrumente) announced their investment to enlarge their current piezo motion facilities ... building will offer 3 floors for multilayer piezo ceramic assembly production in addition ...
(Date:7/17/2019)... COLLEGE PARK, Md. (PRWEB) , ... July 15, 2019 , ... ... cut DNA so that a certain trait can be removed, replaced, or edited, but ... Maryland, is looking far beyond these traditional applications in his latest publication in Nature ...
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel is ... from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also are ... Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel is a market ...
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World Congress ... Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. Three ... using field corn to produce biobased materials. , “Corn is a sustainable, abundant ...
Breaking Biology Technology:
Cached News: