HOME >> BIOLOGY >> NEWS
Gene implicated in chronic kidney disease

Durham, N.C. -- Duke University Medical Center researchers have discovered a gene responsible for one form of chronic kidney disease. The disease, called familial focal segmental glomerulosclerosis (FSGS), can lead to complete kidney failure and affects 20 percent of patients on dialysis. The finding could lead to more effective treatments, according to the researchers.

By examining the genetic makeup of one large, multi-generational family with a dominant form of FSGS, the researchers linked a mutant form of the gene called Transient Receptor Potential Cation Channel 6 (TRPC6) to the disease. What's more, because the gene differs in function from those earlier implicated in FSGS, the finding represents a novel mechanism of kidney damage, said Michelle Winn, M.D., a kidney specialist and geneticist at the Duke Center for Human Genetics and lead author of the study.

Drugs that target the ion channel might offer an effective treatment to slow or prevent scarring of the kidney, the primary manifestation of the disease seen in patients, the researchers said. Such channels are pore-like proteins in the membranes of cells thought to control the flow of calcium.

"This gene represents the first ion channel to be associated with FSGS," Winn said. "It's a new mechanism for kidney disease, which may allow us to advance on new treatments as ion channels are known to be amenable to drug therapy."

Winn, along with senior authors Jeffery Vance, M.D. and Paul Rosenberg, M.D., also of Duke, published their findings May 5, 2005, in Science Express, the early online version of the journal Science.

In the United States, the prevalence of FSGS is increasing yearly, with a particularly high incidence among African-Americans, Winn said. The disease attacks tiny filtering units within the kidney called glomeruli -- leading to scarring, or hardening, of this filter. Symptoms of the disease include high blood pressure, an excess of protein in the urine
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-660-1306
Duke University Medical Center
5-May-2005


Page: 1 2 3

Related biology news :

1. Description of a gene implicated in the development of Fanconi anemia and predisposition to cancer
2. Landmark study identifies large number of new proteins implicated in Huntingtons disease
3. New protein implicated in autism
4. Defective movement of cells power plants implicated in commom inherited neurological disorder
5. Cellular traffic backups implicated in skeletal malformations
6. Defects in crucial brain protein implicated in memory loss
7. Cholesterol implicated in progression of fatty liver disease
8. Tissue microenvironment implicated in susceptibility to liver cancer metastases
9. New genes implicated in rheumatoid arthritis
10. Fake malaria drug implicated in Burmese mans death
11. Pituitary hormone implicated in bone loss after menopause

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... 25, 2017 , ... Leaders of Quorum Review IRB and ... sessions at this week’s Association of Clinical Research Professionals (ACRP) 2017 Meeting & ... research. , "We are excited to present subject matter expertise on topics that impact ...
(Date:4/21/2017)... ... 21, 2017 , ... The University of Connecticut, in partnership ... three startups through the UConn Innovation Fund. The $1.5 million UConn Innovation Fund ... UConn. , The UConn Innovation Fund provides investments of up to $100,000 to ...
(Date:4/20/2017)... Linda, Ca (PRWEB) , ... April 20, 2017 ... ... University Virtual Event , this new webinar will explore challenging patient cases when ... admitted to the hospital, there may be a need for bridging parental anticoagulation ...
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, a learning technology veteran, ... of experience in the learning technologies industry, Mastin joins NetDimensions from the New York ... plc (LTG). At LEO, Mastin served as SVP of the North America offices and ...
Breaking Biology Technology:
Cached News: