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Gene linked with mental illness shapes brain region, researchers find

DALLAS Nov. 7, 2006 -- A gene variant associated with mental illness goes hand-in-hand with enlargement of a brain region that handles negative emotions, researchers at UT Southwestern Medical Center and the Central Texas Veterans Health Care System have found.

The region of the brain called the pulvinar is larger and contains more nerve cells in humans who carry the gene.

"This might indicate that the brain regions that receive input from the pulvinar are more strongly influenced in such individuals, and the pulvinar communicates with brain regions involved in negative emotional issues," said Dr. Dwight German, professor of psychiatry at UT Southwestern and senior author of a study available online and in a future issue of Biological Psychiatry.

The researchers focused on a gene related to the neurotransmitter serotonin, one of the chemical messengers that nerves use to communicate with one another. Once specific nerve cells release serotonin, a molecule called the serotonin transporter (SERT) brings it back into the cell. Thus, serotonin has only a brief influence on the target neurons. Drugs that prevent this re-uptake, such as Prozac, are frequently used to treat patients with depression.

The serotonin transporter gene has two forms, or variants: short, or SERT-s, and long, SERT-l. A person can have two copies of the short gene, one copy each of the short and long, or two copies of the long gene. It is estimated that about 17 percent of the population has two copies of the SERT-s gene.

People carrying two SERT-s genes are more sensitive to emotional stimuli and more likely to experience depression than people with one or no SERT-s genes.

The researchers studied brains from 49 deceased people, with and without psychiatric illnesses. The brains were sliced thinly, the size of the pulvinar measured, the number of nerve cells counted, and the variety of each individual's SERT gene analyzed.
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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
7-Nov-2006


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