HOME >> BIOLOGY >> NEWS
Gene mutation may influence age at onset of Parkinson's disease

The number of mutations in a gene previously found to be associated with early-onset Parkinson's disease may influence the age at which the condition develops; even individuals who carry just one mutated copy may be more susceptible to Parkinson's disease, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

Parkinson's disease affects about 1 percent of individuals age 60 years or older and 4 to 5 percent of those age 85 years or older, according to background information in the article. The neurodegenerative disorder is characterized by tremors, rigid movements, difficulty walking and a mask-like facial appearance. Though much about the development of Parkinson's disease remains unknown, family history has been found to significantly increase risk. Researchers have located several genes that may be implicated, including the parkin gene. About 50 percent of individuals with "juvenile" parkinsonism (in which features of Parkinson's disease develop before age 21 years) and 10 to 25 percent of those with early-onset (before age 50) Parkinson's disease have mutated parkin genes.

Mei Sun, M.D., Ph.D., Massachusetts General Hospital and Harvard Medical School, Boston, and colleagues studied 183 families in which two or more members had Parkinson's disease. The families also met one of two other criteria: either one individual in the family developed Parkinson's disease before age 54 years, or two affected siblings had identical versions of the parkin gene. Because siblings inherit one chromosome from their mother and one chromosome from their father, they can share either zero, one or two versions of each gene. At least one member of each family underwent comprehensive genetic screening to determine the number and nature of any mutations to the parkin gene.

Twenty-three (12.6 percent) of the families screened contained at least one member with a mutated parkin gene. Among those families, 10 (
'"/>

Contact: Sue McGreevey
617-724-2764
JAMA and Archives Journals
12-Jun-2006


Page: 1 2 3

Related biology news :

1. New gene mutation identified in common type of dementia
2. Researchers identify genetic mutation that may alter tumor cell proliferation
3. p53 gene mutations and inflammation trigger skin cancer
4. Muscle weakness: New mutation identified
5. Researchers discover inherited mutation for leukemia
6. Gene mutation linked to cognition is found only in humans
7. Gene mutation linked to increased athletic performance in whippets
8. Researchers learn more about genetic mutation linked to autism
9. Researchers find gene mutation that causes infertility in male mice
10. Gene mutations linked to hereditary lung disease
11. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... , ... June 04, 2019 , ... ... of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% from ... with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... ... Lajollacooks4u is delighted to announce it has been named as one of ... only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as well ... qualify for the Certificate of Excellence –- an award that only 10 percent of ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... testing company, and Mayo Clinic, have documented significant differences in the prevalence of ... and ethnic populations compared to non-Hispanic White women. Results will be presented at ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A study ... efficient delivery system for the sustained release of human placental stem cell (HPSC)-derived ... was able to deliver CM into the injured kidney, where it helped restore ...
(Date:5/15/2019)... ... 15, 2019 , ... Milton Hershey School® has named William Charles Ballough Harding ... biomedical industry, where he is changing lives by creating solutions to global healthcare challenges ... the vision of our founders – Milton and Catherine Hershey – who always hoped ...
(Date:5/14/2019)... LA JOLLA, Calif. (PRWEB) , ... May 14, 2019 , ... ... announces an office expansion, effectively doubling its space from 2,500 to 5,000 square feet. ... SneakPeek Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: