HOME >> BIOLOGY >> NEWS
Gene mutation may influence age at onset of Parkinson's disease

43 percent) had at least one member with two different mutations; three (13 percent) had at least one member with two copies of the same mutation; and 10 (43 percent) had at least one member with one mutated parkin gene and one normal parkin gene. Individuals with one mutated gene and one normal gene are known as heterozygotes; researchers had not previously determined whether heterozygotes were at increased risk for Parkinson's disease. Patients with parkin mutations developed Parkinson's disease at an average age of 42.9 years. Among the families who were selected because two siblings shared the same version of the parkin gene, heterozygotes developed Parkinson's disease an average of 11.7 years earlier than those with no mutations, and those with two or more mutations developed the condition 13.2 years earlier than heterozygotes.

"In conclusion, parkin mutations are not rare in this selected subset of familial Parkinson's disease samples (12.6 percent)," the authors write. "Single parkin mutations may increase susceptibility to the disease and decrease the onset age of Parkinson's disease (mean onset age, 49.6 years)." The fact that even heterozygotes developed Parkinson's disease at an earlier age than those with two normal copies indicates that the gene's effect may be stronger than previously recognized, and that screening for mutations in the gene may help identify those at risk of developing the condition.

(Arch Neurol. 2006;63:826-832. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: This study was supported by the Bumpus Foundation and grants from the U.S. Public Health Service. The DNA samples contributed by the Parkinson Institute, Istituti Clinici di Perfezionamento, were from the Human Genetic Bank of Patients Affected by Parkinson Disease and Parkinsonisms, supported by a grant from the Italian Telethon Foundation.

Editorial: Genetic Studies Help Expl
'"/>

Contact: Sue McGreevey
617-724-2764
JAMA and Archives Journals
12-Jun-2006


Page: 1 2 3

Related biology news :

1. New gene mutation identified in common type of dementia
2. Researchers identify genetic mutation that may alter tumor cell proliferation
3. p53 gene mutations and inflammation trigger skin cancer
4. Muscle weakness: New mutation identified
5. Researchers discover inherited mutation for leukemia
6. Gene mutation linked to cognition is found only in humans
7. Gene mutation linked to increased athletic performance in whippets
8. Researchers learn more about genetic mutation linked to autism
9. Researchers find gene mutation that causes infertility in male mice
10. Gene mutations linked to hereditary lung disease
11. Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans ... Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 ... Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , ...
(Date:6/11/2019)... ... 10, 2019 , ... Improved Pharma LLC announces the publication of “Predictive and ... The article was published online on April 29th, 2019. The authors are Stephen ... Chen of Purdue University. , The article is the most recent addition to a ...
(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, a ... advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... that provides services to more than one dozen hospitals and surgery centers in ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... and ROANOKE, Va. (PRWEB) , ... June 11, ... ... optimized for microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, ... latest in virtual care. , Mytonomy recently deployed its virtual care ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... applications from the USPTO providing proprietary interest to our methodology, processes, and ... DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep ...
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont ... officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening ... The event, which is supported through a partnership with “Ethiopia Invest”, will run ...
(Date:5/8/2019)... ... ... Atlas is on the large side for a Quarter Horse. He and his owner ... When loping around a corner in late 2017, Atlas tripped and partially tore his right ... to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of her veterinarian, Dr. Colter ...
Breaking Biology Technology:
Cached News: