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Gene mutation may influence age at onset of Parkinson's disease

ain Parkinson's Disease Development

Understanding how mutations in parkin and other genes contribute to Parkinson's disease offers valuable clues to the still-mysterious pathways of its development, write Roger N. Rosenberg, M.D., editor, Archives of Neurology, and Uwe Beffert, Ph.D., both of University of Texas, Southwestern Medical Center, Dallas, in an accompanying editorial.

The editorialists note that if the results of this study are confirmed, they write, they "will require a reexamination of the genetic data associated with Parkinson's disease to take into account the possibility that heterozygous mutations in autosomal recessive genes such as parkin and PINK1 affect the susceptibility and age of onset of Parkinson's disease. These findings are provocative and add a new genetic dimension to the pathogenesis of Parkinson's disease."

(Arch Neurol. 2006;63:807-808. Available pre-embargo to the media at www.jamamedia.org.)


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Contact: Sue McGreevey
617-724-2764
JAMA and Archives Journals
12-Jun-2006


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