HOME >> BIOLOGY >> NEWS
Gene profiling predicts resistance to breast cancer drug Herceptin

PHILADELPHIA -- Using gene chips to profile tumors before treatment, researchers at Harvard and Yale Universities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-positive breast cancer. They say this advance could help further refine therapy for the 25 to 30 percent of breast cancer patients with this class of tumor.

In the February 15 issue of Clinical Cancer Research, the researchers found that HER2-positive tumors that did not respond to Herceptin expressed certain basal markers, growth factors and growth factor receptors. One of these, insulin-growth factor receptor 1(IGF-1R), was associated with a Herceptin response rate that was half that of tumors that did not express IGF-1R.

They also discovered that resistant tumors continue to over-express the HER2 growth factor protein -- an important finding given that many scientists had thought that loss of HER2 was likely responsible for Herceptin resistance.

"Herceptin has revolutionized the care of HER2-positive breast cancer for many patients, but unfortunately, not for some. This work demonstrates that digging deeper into the molecular subtypes of these tumors helps us understand why some tumors are resistant and may point to ways to remedy that," said the studys lead author, Lyndsay Harris, M.D., associate professor and Director of the Breast Cancer Disease Unit at Yale University Medical Center.

If additional studies validate these findings, it may be possible to select those patients that will be resistant to Herceptin and treat them with additional drugs to restore Herceptin sensitivity, according to Harris. "Our goal is to see what the tumor tells us before any treatment starts and tailor therapy accordingly," she said.

To determine Herceptin sensitivity, investigators took a small tumor biopsy from 48 patients with newly diagnosed and operable stage II/III breast cancer. They examined the biopsy t
'"/>

Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
20-Feb-2007


Page: 1 2 3

Related biology news :

1. Prediction of graft-versus-host disease by gene-expression profiling of donors and more
2. Three new lung tumor subtypes identified in DNA profiling study
3. Preterm birth risk quickly and accurately detected with proteomic profiling
4. miRNA profiling
5. Gene expression profiling aids in ovarian cancer prognosis
6. Powerful toolkit developed for functional profiling of yeast genes
7. Gene predicts better outcome as cortex normalizes in teens with ADHD
8. Marker predicts pancreatic cancer outcome after surgery, Jefferson surgeon finds
9. Major study predicts grim future for Europes seas
10. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
11. NASA predicts nongreen plants on other planets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2019)... ... 30, 2019 , ... Researchers from Ambry Genetics ... differences in the prevalence of hereditary genetic mutations, also called germline mutations, linked ... Results will be presented at the 2019 American Society of Clinical Oncology (ASCO) ...
(Date:5/26/2019)... ... 24, 2019 , ... Zolgensma (Novartis, AveXis), an AAV-delivered gene therapy used to ... in the United States by the Food and Drug Administration today. , ... genetic disorders in the United States and the second-ever approved treatment for SMA. , ...
(Date:5/23/2019)... ... 2019 , ... Inference Solutions , a global provider ... its inclusion in DMG Consulting’s 2019-2020 Intelligent Virtual Agent Product and Market Report. ... leader, based on number of customers, with 15.8% share of the global market. ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... ... an albino, deaf Great Dane. His owners rescued him when he was four months old ... hearing impairment, he was always an active and playful pup. Frank bonded with his brother, ... the two grew, playtime became rougher and Frank ended up injuring his right rear leg. ...
(Date:4/16/2019)... ... April 16, 2019 , ... On April 24th, ... the U.S. Army Center for Environmental Health Research (USACEHR), with an award for ... Blue Sources, a veteran-owned company located at the Frederick Innovative Technology Center, Inc. ...
(Date:4/12/2019)... ... April 12, 2019 , ... ... in neurotechnology and will educate about innovative tools and devices being used to ... listings for more information. , This segment of Advancements will focus on Sound ...
(Date:4/9/2019)... ... April 09, 2019 , ... ... increasing the capacity of life sciences organizations to accelerate innovation and maximize productivity, ... in the past 12 months. , USDM’s Cloud Assurance is ...
Breaking Biology Technology:
Cached News: