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Gene regulation, not just genes, is what sets humans apart

ow dietary changes have contributed to the current human pandemics of obesity and diabetes, and perhaps there will be some insights from understanding how these regulatory sequences have evolved, he said.

To do a genome-wide analysis of regulatory regions, Haygood and post-doctoral fellow Olivier Fedrigo had to adapt some of the statistical tools used for genome-wide analysis of coding regions. To be sure their results would be robust, they focused on just the most reliably accurate published DNA sequences in common between the three animals, discarding two-thirds of the genome to ensure accuracy. With only three species, we had to be very stringent about quality, Fedrigo said.

The researchers dont think these findings will be of any help resolving questions about how and when the ancestors of humans and chimps diverged on the tree of life, but its safe to say that most of this is ancient history, Wray said.


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Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University
12-Aug-2007


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