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Gene-specific Ebola therapies protect non-human primates from lethal disease

s antisense phosphorodiamidate morpholino oligomers, or PMOs, the team first performed a series of studies to identify PMOs that demonstrated activity against Ebola virus. Next, three of the PMOs were tested in mice, both individually and in combination. The combination of all three was found to be the most effective therapeutic approach in mice, whether the PMOs were administered before or after Ebola infection. Combination therapy was also tested in guinea pigs, where it appeared to be most effective when administered after infection.

To further evaluate the efficacy of the three-PMO combination, four rhesus monkeys were treated with the drug two days prior to Ebola virus exposure. Three of the four were protected from Ebola infection.

"These results, while preliminary, are very encouraging," said Colonel George W. Korch, USAMRIID commander, "especially when you consider that Ebola virus has, to date, been fairly intractable to effective treatment. We look forward to additional findings of success using these PMOs."


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Contact: Caree Vander Linden
Caree.Vanderlinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
12-Jan-2006


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