HOME >> BIOLOGY >> NEWS
Gene-specific Ebola therapies protect non-human primates from lethal disease

s antisense phosphorodiamidate morpholino oligomers, or PMOs, the team first performed a series of studies to identify PMOs that demonstrated activity against Ebola virus. Next, three of the PMOs were tested in mice, both individually and in combination. The combination of all three was found to be the most effective therapeutic approach in mice, whether the PMOs were administered before or after Ebola infection. Combination therapy was also tested in guinea pigs, where it appeared to be most effective when administered after infection.

To further evaluate the efficacy of the three-PMO combination, four rhesus monkeys were treated with the drug two days prior to Ebola virus exposure. Three of the four were protected from Ebola infection.

"These results, while preliminary, are very encouraging," said Colonel George W. Korch, USAMRIID commander, "especially when you consider that Ebola virus has, to date, been fairly intractable to effective treatment. We look forward to additional findings of success using these PMOs."


'"/>

Contact: Caree Vander Linden
Caree.Vanderlinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
12-Jan-2006


Page: 1 2

Related biology news :

1. Ebola outbreaks killing thousands of gorillas and chimpanzees
2. Ebola-outbreak kills 5000 gorillas
3. Gorilla susceptibility to Ebola virus: the cost of sociality
4. Charting the path of the deadly Ebola virus in central Africa
5. Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
6. Ebola virus: from wildlife to dogs
7. Study links Ebola outbreaks to animal carcasses
8. New asthma gene could lead to new therapies
9. Scientists decode RNA mystery, will help aim drug therapies
10. Genomic signatures identify targeted therapies for lung cancer
11. Existence of muscle-building stem cells points to regenerative therapies for muscular disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2019)... Mass. (PRWEB) , ... December 17, 2019 , ... ... R. Murrow Center for a Digital World at The Fletcher School, Tufts University, ... that will enhance the digital learning experience of students using Macmillan Learning’s acclaimed ...
(Date:12/14/2019)... ... December 11, 2019 , ... Fiberstar, Inc., a global market ... won the 2019 Food Ingredient Europe’s plant-based innovation award. , This prestigious award ... category. Fiberstar who was one of three finalists achieved this award by introducing ...
(Date:12/4/2019)... , ... December 04, 2019 , ... ... Dr. Marque Todd , a regulatory toxicology expert with more than 20 ... an Expert Consultant. , Dr. Todd has extensive experience with a variety ...
Breaking Biology News(10 mins):
(Date:1/23/2020)... , ... January 22, 2020 , ... ... developments in the cosmetic surgery industry at two recent North American investor forums ... at the Canaccord Genuity Medical Technologies & Diagnostics Forum on November 21, 2019 ...
(Date:1/22/2020)... ... January 21, 2020 , ... QCDx , a private ... a simple blood draw, today announced the sale of the proprietary RareScope™ instrument to ... will be used in clinical cancer research. , “The RareScope can detect and isolate ...
(Date:1/8/2020)... ... January 08, 2020 , ... Anomet ... achieve specific properties for use in harsh environments inside or outside of the ... to three metals or alloys to achieve specific properties such as corrosion-resistance, biocompatibility, ...
(Date:1/7/2020)... Mass. (PRWEB) , ... January 06, 2020 , ... ... for a Digital World at The Fletcher School at Tufts University, is pleased ... Sloan Foundation. The grant will be administered by Tufts University, and will help ...
Breaking Biology Technology:
Cached News: