HOME >> BIOLOGY >> NEWS
Gene therapy inhibits epilepsy in animals

For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats.

"We have shown that there is a window to intervene after a brain insult to reduce the risk that epilepsy will develop," said one of the lead researchers, Amy R. Brooks-Kayal, M.D., a pediatric neurologist at The Children's Hospital of Philadelphia and associate professor of Neurology and Pediatrics at the University of Pennsylvania School of Medicine. "This provides a 'proof of concept' that altering specific signaling pathways in nerve cells after a brain insult or injury could provide a scientific basis for treating patients to prevent epilepsy."

Dr. Brooks-Kayal and Shelley J. Russek, Ph.D., of Boston University School of Medicine were senior authors of the study in the Nov. 1 Journal of Neuroscience.

Working in a portion of the brain called the dentate gyrus, the researchers focused on one type of cell receptor, type A receptors, for the neurotransmitter gamma-aminobutyric acid (GABA). When GABA(A) receptors are activated, they inhibit the repetitive, excessive firing of brain cells that characterizes a seizure. Seizures are thought to occur, at least in part, because of an imbalance between two types of neurotransmitters: the glutamate system, which stimulates neurons to fire, and the GABA system, which inhibits that brain activity.

GABA's inhibitory role is considered particularly important in the dentate gyrus because the dentate gyrus acts as a gateway for brain activity into the hippocampus, an area that is critical to generating seizures in temporal lobe epilepsy, the most common type of epilepsy in children and adults.

GABA(A) receptors are made up of five subunits--proteins that play important roles in brain development and in
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
8-Nov-2006


Page: 1 2

Related biology news :

1. Testosterone replacement therapy: How safe for aging men?
2. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
3. Aggressive therapy best for certain AML patients
4. Under magnetic force, nanoparticles may deliver gene therapy
5. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
6. Stem cell therapy rescues motor neurons in ALS model
7. Study identifies new gene therapy tools for inherited blindness
8. Breast cancer and hormone therapy -- A looking-glass mirror?
9. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
10. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online ... with Dr. James L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology ... announced on June 16 that starting July 5 it would begin offering ...
(Date:6/11/2020)... ... June 08, 2020 , ... Cryo-Cell International’s announcement comes on ... workers in the medical field. The face masks will be distributed nationwide to ... every day to provide healthcare to pregnant women. The delivery of masks is ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... barcode and RFID labeling software developer and solutions provider, today reported that ... improved labeling accuracy and compliance by 100%, resulting in greater efficiency for ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... , ... May 29, 2020 , ... ... Medical Officer 360°, the first newsletter solely dedicated to the unique role of ... wide range of perspectives on the responsibilities, problem-solving, best practices and career development ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... trials will cause long-term harm , Contrary to conventional wisdom that says the ... finds many companies will emerge from the pandemic commercially weaker, dealing with ...
(Date:5/15/2020)... ... May 14, 2020 , ... ... mesenchymal stem/stromal cell (hMSC) working cell banks and hMSC bioprocess systems, today ... and multi-format collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is the only ...
(Date:5/14/2020)... ... 12, 2020 , ... DuPont Nutrition & Biosciences (N&B) has ... personal care ingredients in Russia and Belarus. Beginning May 1, Interdisp JCS will ... care. , The GENENCARE®OSMS product line contains a range of all-natural, ...
Breaking Biology Technology:
Cached News: