HOME >> BIOLOGY >> NEWS
Gene therapy prevents the onset of diabetic symptoms in mice

PITTSBURGH, Penn. - Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice by inserting a gene encoding for a cytokine -- a protein that stimulates or inhibits the proliferation or function of immune cells -- into their insulin-producing cells. According to the investigators, these findings, which are being presented at the American Society of Gene Therapy Annual Meeting in Baltimore, May 31 to June 4, have significant implications for the prevention of type 1 diabetes.

More than 700,000 Americans have type 1 diabetes, an autoimmune disorder in which the body errantly attacks the cells of the insulin-producing cells of the pancreas, causing chronic hyperglycemia and complications such as blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile diabetes, type 1 diabetes is usually diagnosed at a very early age but is sometimes not diagnosed until the individual reaches adulthood.

In this study, the Pitt researchers used a gene-delivery vehicle known as an adeno-associated virus to insert genes for either of two cytokines, interleukin-4 (IL-4) or interleukin-10 (IL-10), into the insulin-producing beta cells of non-obese diabetic (NOD) mice. Following gene delivery, expression of IL-4 in beta cells prevented the onset of hyperglycemia in NOD mice, whereas beta cell expression of IL-10 accelerated the onset of hyperglycemia.

According to lead author Khaleel Rehman Khaja, Ph.D., senior research associate, department of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, results from this animal study suggest that gene therapy is a viable method for preventing the onset of type 1 diabetes in genetically at-risk people.

"We know that the prevention of type 1 diabetes requires early intervention in the autoimmune process directed against beta cel
'"/>


2-Jun-2006


Page: 1 2

Related biology news :

1. Testosterone replacement therapy: How safe for aging men?
2. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
3. Aggressive therapy best for certain AML patients
4. Under magnetic force, nanoparticles may deliver gene therapy
5. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
6. Stem cell therapy rescues motor neurons in ALS model
7. Study identifies new gene therapy tools for inherited blindness
8. Breast cancer and hormone therapy -- A looking-glass mirror?
9. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
10. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2019)... (PRWEB) , ... June 03, 2019 , ... Stay on ... biotech, medical device and food industries. Access to all webinars is free, so be ... relevant in your field! , Visit http://www.xtalks.com to see our upcoming webinars: ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers ... Mayo Clinic, have documented significant differences in the prevalence of hereditary genetic mutations, ... compared to non-Hispanic White women. Results will be presented at the 2019 American ...
(Date:5/31/2019)... ... May 31, 2019 , ... The OilComm ... Houston, TX, announced today that Ben Reiter, Senior Writer at Sports Illustrated and ... October 3rd.     , Reiter predicted the Houston Astros would win the MLB championship ...
Breaking Biology News(10 mins):
(Date:5/21/2019)... Ethiopia (PRWEB) , ... May 21, 2019 , ... ... Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated ... and malting industry in Africa. The event, which is supported through a partnership ...
(Date:5/14/2019)... HARBOR TOWNSHIP, N.J. (PRWEB) , ... May 13, ... ... manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical ... completely new Heliumleak.com company website. The redesigned website aims to improve LDA’s ability ...
(Date:5/7/2019)... ... 06, 2019 , ... "The new Liquid Nitrogen Best Practices ... asked to store cellular products being used in adoptive therapy research and ... leaders, who have shared their expertise in building and managing facilities to support ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... 9001:2015 standard, REPROCELL USA Inc. has demonstrated its ability to provide various ... Inc. aims to enhance customer satisfaction through the effective implementation of its ...
Breaking Biology Technology:
Cached News: