HOME >> BIOLOGY >> NEWS
Gene therapy prevents the onset of diabetic symptoms in mice

PITTSBURGH, Penn. - Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice by inserting a gene encoding for a cytokine -- a protein that stimulates or inhibits the proliferation or function of immune cells -- into their insulin-producing cells. According to the investigators, these findings, which are being presented at the American Society of Gene Therapy Annual Meeting in Baltimore, May 31 to June 4, have significant implications for the prevention of type 1 diabetes.

More than 700,000 Americans have type 1 diabetes, an autoimmune disorder in which the body errantly attacks the cells of the insulin-producing cells of the pancreas, causing chronic hyperglycemia and complications such as blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile diabetes, type 1 diabetes is usually diagnosed at a very early age but is sometimes not diagnosed until the individual reaches adulthood.

In this study, the Pitt researchers used a gene-delivery vehicle known as an adeno-associated virus to insert genes for either of two cytokines, interleukin-4 (IL-4) or interleukin-10 (IL-10), into the insulin-producing beta cells of non-obese diabetic (NOD) mice. Following gene delivery, expression of IL-4 in beta cells prevented the onset of hyperglycemia in NOD mice, whereas beta cell expression of IL-10 accelerated the onset of hyperglycemia.

According to lead author Khaleel Rehman Khaja, Ph.D., senior research associate, department of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, results from this animal study suggest that gene therapy is a viable method for preventing the onset of type 1 diabetes in genetically at-risk people.

"We know that the prevention of type 1 diabetes requires early intervention in the autoimmune process directed against beta cel
'"/>


2-Jun-2006


Page: 1 2

Related biology news :

1. Testosterone replacement therapy: How safe for aging men?
2. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
3. Aggressive therapy best for certain AML patients
4. Under magnetic force, nanoparticles may deliver gene therapy
5. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
6. Stem cell therapy rescues motor neurons in ALS model
7. Study identifies new gene therapy tools for inherited blindness
8. Breast cancer and hormone therapy -- A looking-glass mirror?
9. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
10. Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
11. Scientists follow familiar TRAIL to new cancer therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/22/2019)... (PRWEB) , ... October 21, 2019 , ... Join ... MS, Director of Bioanalytical in a live session on Thursday, October 31, ... CRO partner. , A good CRO partner should have expertise in method development, ...
(Date:10/17/2019)... (PRWEB) , ... October 15, 2019 , ... ... Prepared Media for the Microbiological Community”. , Microbiology International currently manufactures ready-to-use culture ... company also offers pre-poured agar plates & liquid supplements. , This major step ...
(Date:10/15/2019)... ... 2019 , ... Erchonia, the global leader in the manufacturing ... in Orlando & 18th Annual Golf Tournament. The invite-only, four-day event starts ... Melbourne. , The first day will kick off with training and roundtable discussions ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared ... Health Organization, with MRSA becoming one of the most serious concerns. Hong Kong cannot ... cases of community-associated MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – ...
(Date:9/24/2019)... , ... September 24, 2019 , ... In the past ... research led by faculty at South Dakota School of Mines & Technology ... microbes that attach to surfaces to form a slimy and yet strong layer which ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... ... was co-located with the China Focus @ Biotech Week Boston, a forum organized ... and collaborations in healthcare innovation. , After a careful process of evaluation, twelve ...
Breaking Biology Technology:
Cached News: