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Gene therapy protects mice from the effects of whole-body irradiation

BALTIMORE, June 3 University of Pittsburgh School of Medicine researchers have successfully protected mice against the damaging effects that radiation can have on bone marrow using gene therapy. Based on these results, the researchers believe this approach may be able to protect first responders in the event of a radiological accident or the detonation of a crude radiological weapon, or "dirty bomb." The findings are being presented at the American Society of Gene Therapy annual meeting in Baltimore, May 31 to June 4.

Since the events of Sept.11, there has been growing concern that terrorists may use a dirty bomb--a conventional explosive wrapped in radiological material--or attack a nuclear power facility to disperse high-dose radiation across a populated area. Experts believe a significant number of the population would die within 30 days of exposure to a high dose of radiation from such an event, which has prompted the federal government to fund efforts to develop medical interventions against radiological and nuclear threats.

In this study, Pitt researchers used gene therapy to deliver the compound manganese superoxide dismutase-plasmid liposome (MnSOD-PL) to the cells of female mice. Twenty-four hours later, groups of mice that received the treatment and control mice that did not were exposed to varying doses of whole body radiation. Following irradiation, the mice were weighed daily and observed for signs of irradiation-induced damage to their bone marrow. Control mice irradiated at the higher doses lost weight and died fairly rapidly due to bone marrow damage. In contrast, mice treated with the MnSOD-PL gene therapy showed no changes in body weight, had little bone-marrow damage, and lived longer compared to the control irradiated mice.

According to corresponding author Joel S. Greenberger, M.D., professor and chair of the department of radiation oncology and co-director of the Lung Cancer Center at the University of Pittsburgh Cancer
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