HOME >> BIOLOGY >> NEWS
Gene-transcription machinery seen poised for action, held in check until needed

(PHILADELPHIA) For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes. Now, a new study led by researchers at The Wistar Institute suggests that the gene-transcription machinery, once in place, can remain poised for action but held in check until a triggering signal sends it on its way down the linear DNA molecule.

The data outline a mechanism by which sets of critical genes could be prepared for nearly instantaneous activation in response to stress or other vital needs. Embryonic stem cells, for example, are known to have numbers of genes held in this state of readiness.

In their investigations, the scientists were able to identify a single molecule called ubiquitin that, when in place, appears to be able to pause the transcription process after the needed machinery has been assembled. Once that molecule is removed, the machinery with a molecule known as RNA polymerase II at its core is released and transcription is set into motion. The research was done in yeast, an often-used model organism for genetic studies. A report on the findings appears in the current issue of Molecular Cell.

In our experiments, we saw polymerase loaded onto the gene, but not correctly activated, says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. At the appropriate time, ubiquitin is removed, and this triggers polymerase action. Data from other laboratories indicate that stem cells have many genes that may be poised in this way, ready to send the cells down various differentiation pathways to form different tissues. There are likely many vital cell functions that depend on a quick response which could be regulated by this process.

In earlier work, Berger and her coworkers looked at ways in which
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
25-Jul-2007


Page: 1 2

Related biology news :

1. Biologists probe the machinery of cellular protein factories
2. Dissecting the machinery of nicotines reward
3. Reactive oxygen species shown essential for development of inner ears balance machinery
4. Delving deeper into the machinery of cocaine addiction
5. Clearing jams in copy machinery
6. Gambling monkeys give insight into neural machinery of risk
7. Immune cells genetic jam session is controlled by cell division machinery
8. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
9. Commandeering cellular machinery: recognition mechanism to detect small molecules
10. Thorium poised to meet worlds energy needs
11. 3D ultrasound device poised to advance minimally invasive surgery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: