HOME >> BIOLOGY >> NEWS
Gene variant increases risk for alcoholism following childhood abuse

Girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the bodys response to stress, according to a new study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). The new finding could help explain why some individuals are more resilient to profound childhood trauma than others.

With this study we see yet again that nature and nurture often work together, not independently, to influence our overall health and well-being, says NIH Director Elias A. Zerhouni, M.D.

This finding underscores the central role that gene-environment interactions play in the pathogenesis of complex diseases such as alcoholism, adds NIAAA Director Ting-Kai Li, M.D. A report of the study appears in the June 26, 2007 advance online publication of Molecular Psychiatry.

Previous studies have shown that childhood sexual abuse increases the risk for numerous mental health problems in adulthood. However not all abused children develop such problems, a likely indication that genetic factors also play a role. Recent studies have linked the monoamine oxidase A (MAOA) gene with adverse behavioral outcomes stemming from childhood mistreatment.

MAOA is an enzyme that metabolizes various neurotransmitters that regulate the bodys response to stress, explains first author Francesca Ducci, M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic region (MAOA-LPR) -- of the MAOA gene. Two such MAOA-LPR variants occur most frequently and result in high or low MAOA enzyme activity. In a recent study, researchers found that maltreated boys who possessed the low activity MAOA-LPR variant were more likely to develop behavior problems than boys with the high activity variant.

Our
'"/>

Contact: John Bowersox
jbowersox@mail.nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
26-Jun-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Gene variant is associated with brain anatomy, clinical course of ADHD
3. Identified main genetic variants involved in response to HIV
4. Gene variant increases risk of blindness
5. Which genome variants matter?
6. Gene variants reveal susceptibility to cardiovascular disease
7. Genetic variant is associated with higher rate of premature delivery in African-American women
8. Three human gene variants appear to influence tb susceptibility
9. Is brain size linked to two common gene variants?
10. Genetic variants and breast cancer risk, genetics and suicidal behavior, and more
11. Gene variant protects against type 2 diabetes, heart disease, and hypertriglyceridemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... ... June 18, 2020 , ... Biosero ... Data Decisions,” for pharmaceutical and biotech executives, laboratory managers, scientists, researchers and ... instruments and laboratory equipment from dozens of manufacturers into their lab. , ...
(Date:6/11/2020)... (PRWEB) , ... June 08, 2020 , ... ... for masks and other protective measures to protect workers in the medical field. ... their dedicated staffs who valiantly risk their lives every day to provide healthcare ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed ... well-being of our attendees, staff, and the public. We remain committed to creating ... ways to collaborate virtually,” said Julie Sutcliffe, President of WMIS. , ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... , ... June 09, 2020 , ... ... release of the NEON Micro-Tracer Solution, a highly accurate, contact tracing ... virus in the workplace. Contact tracing, a core disease control measure, is a ...
(Date:5/30/2020)... ... May 29, 2020 , ... Medrio, Inc., the leading provider ... has enabled Cytovale, Inc., a medical technology company dedicated to revolutionizing diagnostics for ... first patient in (FPI) in just seven days. The Cytovale technology will allow ...
(Date:5/26/2020)... ... , ... Brilliant , the leading smart home control and lighting company, ... a new integration to bring more convenience, simplicity, and security to the smart home ... can now be controlled from Brilliant’s in-wall touchscreen control panels and mobile app. ...
(Date:5/21/2020)... (PRWEB) , ... May 20, 2020 , ... ... addition of Simon Prakash, who will serve as the company’s executive vice president ... a time when Exo is disrupting the medical imaging space, bringing more than ...
Breaking Biology Technology:
Cached News: