HOME >> BIOLOGY >> NEWS
Gene variant increases risk for alcoholism following childhood abuse

Girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the bodys response to stress, according to a new study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). The new finding could help explain why some individuals are more resilient to profound childhood trauma than others.

With this study we see yet again that nature and nurture often work together, not independently, to influence our overall health and well-being, says NIH Director Elias A. Zerhouni, M.D.

This finding underscores the central role that gene-environment interactions play in the pathogenesis of complex diseases such as alcoholism, adds NIAAA Director Ting-Kai Li, M.D. A report of the study appears in the June 26, 2007 advance online publication of Molecular Psychiatry.

Previous studies have shown that childhood sexual abuse increases the risk for numerous mental health problems in adulthood. However not all abused children develop such problems, a likely indication that genetic factors also play a role. Recent studies have linked the monoamine oxidase A (MAOA) gene with adverse behavioral outcomes stemming from childhood mistreatment.

MAOA is an enzyme that metabolizes various neurotransmitters that regulate the bodys response to stress, explains first author Francesca Ducci, M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic region (MAOA-LPR) -- of the MAOA gene. Two such MAOA-LPR variants occur most frequently and result in high or low MAOA enzyme activity. In a recent study, researchers found that maltreated boys who possessed the low activity MAOA-LPR variant were more likely to develop behavior problems than boys with the high activity variant.

Our
'"/>

Contact: John Bowersox
jbowersox@mail.nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
26-Jun-2007


Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Gene variant is associated with brain anatomy, clinical course of ADHD
3. Identified main genetic variants involved in response to HIV
4. Gene variant increases risk of blindness
5. Which genome variants matter?
6. Gene variants reveal susceptibility to cardiovascular disease
7. Genetic variant is associated with higher rate of premature delivery in African-American women
8. Three human gene variants appear to influence tb susceptibility
9. Is brain size linked to two common gene variants?
10. Genetic variants and breast cancer risk, genetics and suicidal behavior, and more
11. Gene variant protects against type 2 diabetes, heart disease, and hypertriglyceridemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/25/2019)... ... March 25, 2019 , ... Researchers have found multiple ... since it came into use by the scientific community. Keck Graduate Institute (KGI) ... first to combine the power of CRISPR’s nucleic acid targeting with the ultra ...
(Date:3/23/2019)... ... 2019 , ... Artificial Intelligence (AI) is an exciting field ... learning. Machine learning is a branch of AI focused on identifying patterns in ... learning, scientists are able to build predictive models and understand key trends in ...
(Date:3/19/2019)... ... 19, 2019 , ... Nativis, Inc., today announced the Company ... is effective immediately for the clinical stage, therapeutic device company, which is developing ... announcement, Chris Rivera, Chief Executive Officer, said, “the renaming of the company to ...
Breaking Biology News(10 mins):
(Date:3/29/2019)... ... March 28, 2019 , ... Specific Diagnostics announced ... proceeded with a second stage of funding for Specific’s Reveal™ rapid antibiotic susceptibility ... top of the $1.7 million already awarded by CARB-X. The additional $1.7M will ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, ... importance of healthy meals and good nutrition. This month, Chef Jodi Abel appeared ... chef. , The first segment addressed the nutritional value of USDA’s MyPlate, ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has awarded microbiome research ... researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led by Dr. Kingsley ... Department of Medical Laboratory Sciences and Deputy Provost, College of Health Sciences. The ...
(Date:3/19/2019)... N.J. (PRWEB) , ... March 19, 2019 , ... The ... is a great opportunity to see the most cutting-edge cancer research. The Visikol team ... with 3D cell culture assays as well as their digital pathology ...
Breaking Biology Technology:
Cached News: