HOME >> BIOLOGY >> NEWS
Gene variations directly link inflammation to an increased risk for lung cancer

Variations in two genes related to inflammation may be a major risk factor for developing lung cancer, according to a team of scientists from the National Cancer Institute and the University of Texas M. D. Anderson Cancer Center. The effect of these genes is especially strong among heavy smokers, suggesting that the inflammatory response is important in modulating the damage caused by tobacco smoke.

Their study, published in the July 1 issue of Cancer Research, a publication of the American Association for Cancer Research, is the first to pinpoint the mechanism by which damage to the lung might trigger an overzealous inflammatory response by the immune system, leading to lung cancer. The variants, or polymorphisms, were found in genes for interleukin 1A and interleukin 1B, two signaling molecules that immune system cells secrete in response to infection or tissue damage.

Our findings help explain how heavy smoking, for example, combines with a genetic predisposition to create a besieged environment within the lungs, said lead author Eric Engels, M.D., MPH, researcher at the Viral Epidemiology Branch of the NCIs Division of Cancer Epidemiology and Genetics. Essentially, sustained inflammation alters the microenvironment of the lung tissue, damaging cells and altering DNA.

Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could lead to conditions within the lung environment that foster cancer, Engels said. Previous studies have shown that diseases associated with lung damage, such as tuberculosis and asthma, increase the risk of developing lung cancer. Likewise, exposure to tissue-damaging substances like silica and asbestos, inhaled into the lungs, has also been shown to increases lung cancer risk.

Inflammation has long been thought to be a factor in many cancers, including lung cancer, and could provide an explanation how d
'"/>

Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
3-Jul-2007


Page: 1 2

Related biology news :

1. Fever after smallpox vaccination tied to individual genetic variations
2. Cataloging the structural variations in human genetics
3. Study fails to verify gene variations as risk factors for certain cardiovascular problems
4. Vitamin D, variations in its receptor and prostate cancer
5. In Hispanic women, genetic variations linked to spontaneous preterm birth
6. Ethnic variations in hormone levels may cause differences in breast cancer risk
7. Effectiveness of certain antidepressants may be influenced by gene variations of individuals
8. Gene variations may increase stroke risk for younger women
9. A new kind of mutation could explain numerous phenotypic variations in various species
10. Researchers map of genetic variations implicated in disease
11. USC scientists link variations in growth-factor gene to risk of prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... August 29, 2018 , ... ... technology to identify specific chromosomal abnormalities using morphological assessment through artificial intelligence ... and Australia-based Life Whisperer suggests that artificial intelligence (AI) models, ...
(Date:8/26/2018)... ... August 25, 2018 , ... Maire Mayne, an ... energy treated nutraceutical to reduce inflammation and autoimmune disorders and improve overall immune ... well as inflammation. The following data was reported:,     Over ...
(Date:8/23/2018)... ... 22, 2018 , ... RURO, Inc., an industry-leading lab software ... rapidly growing cloud-based laboratory information system. , With the success of the streamlined ... digit growth throughout 2018, the RURO team has been hard at work expanding ...
Breaking Biology News(10 mins):
(Date:8/26/2018)... ... August 24, 2018 , ... ExoCoBio Inc., based ... relieves atopic dermatitis and inhibits a variety of inflammatory targets in the journal ... symptoms of mice having severe atopic dermatitis were significantly improved after administration of ...
(Date:8/21/2018)... ... 2018 , ... The Connecticut Technology Council (CTC) and Marcum LLP today announce ... companies in Connecticut. This year’s group of top-ranked companies will be honored at the ... Convention Center in Hartford. A complete list of the Marcum Tech Top 40 is ...
(Date:8/17/2018)... Columbia (PRWEB) , ... August 17, 2018 , ... ... International Society for Biological and Environmental Repositories (ISBER) is pleased to announce the ... , The Fourth Edition publication, originally released in January 2018, is a practice-changing ...
(Date:8/11/2018)... N.J. (PRWEB) , ... August 10, 2018 , ... Researchers ... fracturing while under pressure. The Explosion Protection Chamber for High-Pressure NMR & EPR ... new level of safety to the laboratory. , High-pressure experiments have significantly grown ...
Breaking Biology Technology:
Cached News: