HOME >> BIOLOGY >> NEWS
Gene variations may increase stroke risk for younger women

University of Maryland researchers have shown a strong association between specific genetic variations and an increased risk of stroke in younger women, adding to the growing evidence of possible genetic influences in stroke. The study results, which appear in the August issue of Human Molecular Genetics, indicate an increased risk ranging from 50 to 100 percent depending on the particular genetic variation.

"This finding is another important step in understanding the role genes may play in stroke," says study author John W. Cole, M.D., M.S., a research staff physician at the Baltimore Veterans Affairs Medical Center and an assistant professor of neurology at the University of Maryland School of Medicine.

He adds, "We have verified that specific variations, or polymorphisms, that occur within a particular gene are associated with increased stroke risk; now we need to explore why. With a better understanding of these polymorphisms, we may someday develop a genetic test to identify women who may be at greater risk of stroke. These women could receive more intensive screening and counseling for other stroke risk factors such as smoking, high blood pressure and the use of oral contraceptives."

The University of Maryland researchers looked for the genetic variations in a group of more than 400 African-American and Caucasian women between the ages of 15 and 49, half of whom had suffered an ischemic stroke (caused by a blood clot in the brain). Previous studies had linked variations in a specific gene, phosphodietsterase 4D (PDE4D), to an increased risk of stroke in populations of older men.

The Maryland group evaluated more than two dozen variations in the PDE4D gene and was the first to verify an increased risk of stroke in younger women. Five variants were found to be associated with increased stroke risk. The researchers also found that smokers who have one of these variants are at much higher risk and the more they smoke, the greater the ch
'"/>

Contact: Ellen Beth Levitt
eblevitt@umm.edu
410-328-8919
University of Maryland Medical Center
1-Aug-2006


Page: 1 2

Related biology news :

1. Gene variations directly link inflammation to an increased risk for lung cancer
2. Fever after smallpox vaccination tied to individual genetic variations
3. Cataloging the structural variations in human genetics
4. Study fails to verify gene variations as risk factors for certain cardiovascular problems
5. Vitamin D, variations in its receptor and prostate cancer
6. In Hispanic women, genetic variations linked to spontaneous preterm birth
7. Ethnic variations in hormone levels may cause differences in breast cancer risk
8. Effectiveness of certain antidepressants may be influenced by gene variations of individuals
9. A new kind of mutation could explain numerous phenotypic variations in various species
10. Researchers map of genetic variations implicated in disease
11. USC scientists link variations in growth-factor gene to risk of prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... NEW YORK , Feb. 7, 2017 /PRNewswire/ ... point. Driven largely by the confluence of organizations, ... users, distaste for knowledge-based systems (password and challenge ... consumer, industrial, and government systems. The market is ... been a demarcation between consumer and enterprise uses ...
(Date:2/6/2017)... , Feb. 6, 2017 According ... security are driving border authorities to continue to ... reports there are 2143 Automated Border Control (ABC) ... currently deployed at more than 163 ports of ... 2013 to 2016 achieving a combined CAGR of ...
(Date:2/2/2017)... 2017  Central to its deep commitment to ... The Japan Prize Foundation today announced the laureates ... the envelope in their respective fields of Life ... are being recognized with the 2017 Japan Prize ... contribute to the advancement of science and technology, ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... 2017  ImMAGE Biotherapeutics (OTCMKTS: IMMG), an early-stage biotechnology company ... better treatment for triple negative breast cancer (TNBC), announced today ... program. The YEi Start in ... help entrepreneurs grow their business in France ... companies selected to complete an intensive one week immersion in ...
(Date:2/16/2017)... 16, 2017   Capricor Therapeutics, Inc. ... company developing first-in-class biological therapies for cardiac and ... elected to terminate its license agreement with the ... including Cenderitide. "Our decision to return ... prioritize our efforts to advance our core cell ...
(Date:2/16/2017)... N.J. , Feb. 16, 2017  Champions Oncology, ... in the development and sale of advanced technology solutions ... oncology drugs, today announced the addition of new cohorts ... These new models will expand Champions, product line ... head and neck cancer, AML, and non-small cell lung ...
(Date:2/16/2017)... ... February 16, 2017 , ... ... further extended its industry leading Biochemistry Services specifically targeting the rapidly growing ... and methods for the biochemical and biosimilar characterization , product-related impurity ...
Breaking Biology Technology:
Cached News: