HOME >> BIOLOGY >> NEWS
Gene variations may increase stroke risk for younger women

University of Maryland researchers have shown a strong association between specific genetic variations and an increased risk of stroke in younger women, adding to the growing evidence of possible genetic influences in stroke. The study results, which appear in the August issue of Human Molecular Genetics, indicate an increased risk ranging from 50 to 100 percent depending on the particular genetic variation.

"This finding is another important step in understanding the role genes may play in stroke," says study author John W. Cole, M.D., M.S., a research staff physician at the Baltimore Veterans Affairs Medical Center and an assistant professor of neurology at the University of Maryland School of Medicine.

He adds, "We have verified that specific variations, or polymorphisms, that occur within a particular gene are associated with increased stroke risk; now we need to explore why. With a better understanding of these polymorphisms, we may someday develop a genetic test to identify women who may be at greater risk of stroke. These women could receive more intensive screening and counseling for other stroke risk factors such as smoking, high blood pressure and the use of oral contraceptives."

The University of Maryland researchers looked for the genetic variations in a group of more than 400 African-American and Caucasian women between the ages of 15 and 49, half of whom had suffered an ischemic stroke (caused by a blood clot in the brain). Previous studies had linked variations in a specific gene, phosphodietsterase 4D (PDE4D), to an increased risk of stroke in populations of older men.

The Maryland group evaluated more than two dozen variations in the PDE4D gene and was the first to verify an increased risk of stroke in younger women. Five variants were found to be associated with increased stroke risk. The researchers also found that smokers who have one of these variants are at much higher risk and the more they smoke, the greater the ch
'"/>

Contact: Ellen Beth Levitt
eblevitt@umm.edu
410-328-8919
University of Maryland Medical Center
1-Aug-2006


Page: 1 2

Related biology news :

1. Gene variations directly link inflammation to an increased risk for lung cancer
2. Fever after smallpox vaccination tied to individual genetic variations
3. Cataloging the structural variations in human genetics
4. Study fails to verify gene variations as risk factors for certain cardiovascular problems
5. Vitamin D, variations in its receptor and prostate cancer
6. In Hispanic women, genetic variations linked to spontaneous preterm birth
7. Ethnic variations in hormone levels may cause differences in breast cancer risk
8. Effectiveness of certain antidepressants may be influenced by gene variations of individuals
9. A new kind of mutation could explain numerous phenotypic variations in various species
10. Researchers map of genetic variations implicated in disease
11. USC scientists link variations in growth-factor gene to risk of prostate cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene variations may increase stroke risk for younger women

(Date:10/16/2014)... have challenged conventional thinking on how the bowel lining ... for how bowel cancer starts. , The researchers produced ... regenerating the ,crypts, that are a feature of the ... in bowel cancer development, a controversial finding as scientists ... Using 3D imaging technologies, Dr Chin Wee Tan and ...
(Date:10/16/2014)... causes severe respiratory tract infections and worldwide claims ... at VIB and Ghent University have succeeded in ... common virus infection. , Xavier Saelens (VIB/UGent): ... the way for the development of a novel ... causes suffering in numerous small children and elderly ...
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
(Date:10/19/2014)... 2014 The Latin American hardware encryption ... Latin America with analysis and forecast of revenue. This ... is expected to reach $2,366.8 million by 2018, at ... Browse through the TOC of the Latin American hardware ... in-depth analysis provided. It also provides a glimpse of ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application ... 2019", analyzes the global market on the basis ... industry details such as the key drivers, current ... , Browse 81 Market Data Tables and 29 ... on “1,6-Hexanediol Market by Application and by Geography ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
Cached News: