Gene's discovery could help prevent a leading cause of blindness in the elderly

PITTSBURGH, Aug. 16 University of Pittsburgh researchers have discovered a gene linked to age-related maculopathy (ARM), the leading cause of untreatable blindness in the elderly. Their discovery suggests a simple test might be able to identify those at risk for what is commonly known as macular degeneration (AMD) and may lead to the development of more effective preventive strategies.

Researchers report that variations of a gene called PLEKHA1 are strongly associated with a person's risk of developing ARM. The results, a culmination of 15 years of research, will be published in the September issue of the American Journal of Human Genetics and are currently available online.

The discovery of the gene came about through the team's efforts to map the genes of 612 families affected by ARM and an additional 323 individuals without a history of macular degeneration. Pooling data from a number of gene mapping studies, researchers were able to identify multiple locations on the chromosomes where there are common gene variants among people with ARM. Specifically, researchers found that a region on one of these chromosomes, chromosome 10, was the one most likely to contain a major gene that influences the risk of ARM. Further analysis of chromosome 10 found that a variation in PLEKHA1 to be strongly associated with a person's risk of developing ARM.

Earlier this year, researchers from Rockefeller University, Yale University, The National Eye Institute, Duke University, Vanderbilt University, University of Texas Southwestern, and Boston University used similar methods to identify the first gene variant thought to be a major contributor to ARM, complement factor H (CFH) on chromosome 1. The Pittsburgh study confirms involvement of this gene and, for the first time, shows that the association results also accounted for findings from previous genetic studies of AMD families. Importantly, the new study found that having both CFH and PLEKHA1 indicate a


Page: 1 2 3

Related biology news :

1. Genes activity points to more lethal subtype of AML
2. Genes mutations found to cause life-threatening aortic disease
3. Enzyme discovery sheds light on vitamin D
4. New proteomics research promises to revolutionize biomedical discovery
5. MU researchers make discovery in molecular mechanics of phototropism
6. International team to honor 30th anniversary of deep-sea vent discovery in Galpagos
7. Screening approach leads to discovery of gene linked to breast cancer
8. Lucky 13 as new gene discovery offers further hope for childhood blindness
9. Plants that produce more vitamin C may result from UCLA-Dartmouth discovery
10. Biting discovery: MU entomologist finds host of new aquatic insect species in Thailand
11. J&JPRD discovery may lead to new treatments for chronic sensitivity, pain caused by cold

Post Your Comments:

(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure ... for glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of ... Fellows are charged with supporting the organization’s initiatives and overall vision. , "Senior ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable ... support testing operations in the fight against the COVID-19 pandemic in Zambia. , ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... ... ... Reducing carbon emissions has been and will continue to be a major ... ways to reduce CO2 is something we can’t avoid. , To protect the ... produced today are created from recycled cooking oil or crops. Unfortunately, these sources are ...
(Date:6/2/2020)... ... June 01, 2020 , ... As part of ... change in the world, enterprise security solutions provider bitsIO donated time to help ... from home during self-quarantines and shelter-in-place orders, companies are increasingly concerned about the ...
(Date:5/30/2020)... ... 29, 2020 , ... The Conference Forum is pleased to ... to the unique role of the Chief Medical Officer in the biotech industry. ... best practices and career development of CMOs and Heads of R&D from different ...
(Date:5/28/2020)... ... May 28, 2020 , ... The Security Industry Association ... the 2020 winners of the Women in Biometrics Awards – a globally ... Biometric Update and the SIA Women in Security Forum . The ...
Breaking Biology Technology:
Cached News: