The PhD, entitled Identification and characterisation of new factors involved in the processes of formation of biofilm from Gram-positive bacteria.
Biofilms are communities of microorganisms in a matrix that joins them together and to living or inert substrates, points out Alejandro Toledo. Although they are widely found in nature, and in many cases have beneficial effects, their study has been boosted on discovering their relation to chronic infections associated to medical implants such as those tissues involving infections of the middle ear, of the prostate gland, pneumonia in patients with cystic fibrosis, osteomyelitis, etc.
In the interior of the biofilm, bacteria present greater resistance to antibiotics, to the opsonisation by antibodies and to phagocytosis, which explains the chronic character of these infections, states the author of the PhD.
The aim of the PhD was the characterisation of the process of formation of the Staphylococcus aureus biofilm.
Regulating mechanisms unknown to date
The starting point for the research was the Bap protein (Biofilm associated protein). Bap, according to the thesis, presents a structural organisation similar to other surface proteins of unknown function in a number of species of bacteria such as: Esp de Enter
Contact: Garazi Andonegi